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Lower versus Traditional Treatment Threshold for Neonatal Hypoglycemia

Authors :: Anne A M W, van Kempen
P Frank, Eskes
Debbie H G M, Nuytemans
Johanna H, van der Lee
Lea M, Dijksman
Nicole R, van Veenendaal
Flip J P C M, van der Hulst
Rob M J, Moonen
Luc J I, Zimmermann
Ellen P, van 't Verlaat
Minouche, van Dongen-van Baal
Ben A, Semmekrot
Hélène G, Stas
Ron H T, van Beek
José J, Vlietman
Peter H, Dijk
Jacqueline U M, Termote
Rogier C J, de Jonge
Amerik C, de Mol
Marianne W A, Huysman
Joke H, Kok
Martin, Offringa
Nicole, Boluyt
Kindergeneeskunde
MUMC+: MA Niet Med Staf Onderz Beh Kindergeneeskunde (9)
RS: GROW - R4 - Reproductive and Perinatal Medicine
RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health
Pediatrics
General Paediatrics
AGEM - Inborn errors of metabolism
APH - Methodology
APH - Quality of Care
Graduate School
AGEM - Digestive immunity
AGEM - Endocrinology, metabolism and nutrition
ARD - Amsterdam Reproduction and Development
Pediatric surgery
Source :: New England Journal of Medicine, 382(6), 534. Massachussetts Medical Society, New England Journal of Medicine, 382(6), 534-544. MASSACHUSETTS MEDICAL SOC, New England Journal of Medicine, 382(6), 534-544. MASSACHUSETTS MEDICAL SOCIETY, New England Journal of Medicine, 382(6), 534-544. Massachussetts Medical Society, New England journal of medicine, 382(6), 534-544. Massachussetts Medical Society, Van Kempen, A A M W, Eskes, P F, Nuytemans, D H G M, Van Der Lee, J H, Dijksman, L M, Van Veenendaal, N R, Van Der Hulst, F J P C M, Moonen, R M J, Zimmermann, L J I, Van'T Verlaat, E P, Van Dongen-Van Baal, M, Semmekrot, B A, Stas, H G, Van Beek, R H T, Vlietman, J J, Dijk, P H, Termote, J U M, De Jonge, R C J, De Mol, A C, Huysman, M W A, Kok, J H, Offringa, M & Boluyt, N 2020, ' Lower versus traditional treatment threshold for neonatal hypoglycemia ', New England Journal of Medicine, vol. 382, no. 6, pp. 534-544 . https://doi.org/10.1056/NEJMoa1905593, Pediatric Neurology Briefs
Publication Year :: 2020
Abstract: BACKGROUND Worldwide, many newborns who are preterm, small or large for gestational age, or born to mothers with diabetes are screened for hypoglycemia, with a goal of preventing brain injury. However, there is no consensus on a treatment threshold that is safe but also avoids overtreatment. METHODS In a multicenter, randomized, noninferiority trial involving 689 otherwise healthy newborns born at 35 weeks of gestation or later and identified as being at risk for hypoglycemia, we compared two threshold values for treatment of asymptomatic moderate hypoglycemia. We sought to determine whether a management strategy that used a lower threshold (treatment administered at a glucose concentration of