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Reproductive outcomes of intracytoplasmic sperm injection using testicular sperm and ejaculated sperm in patients with AZFc microdeletions: a systematic review and meta-analysis
- Source :
- Asian Journal of Andrology, Asian Journal of Andrology, Vol 23, Iss 5, Pp 495-500 (2021)
- Publication Year :
- 2021
- Publisher :
- Medknow, 2021.
-
Abstract
- Studies have explored the assisted reproductive technology (ART) outcomes of Y-chromosome azoospermia factor c (AZFc) microdeletions, but the effect of sperm source on intracytoplasmic sperm injection (ICSI) remains unknown. To determine the ART results of ICSI using testicular sperm and ejaculated sperm from males with AZFc microdeletions, we searched Embase, Web of Science, and PubMed to conduct a systematic review and meta-analysis. The first meta-analysis results for 106 cycles in five studies showed no significant differences in the live birth rate between the testicular sperm group and the ejaculated sperm group (risk ratio: 0.97, 95% confidence interval [CI]: 0.73–1.28, P = 0.82). The second meta-analysis of 106 cycles in five studies showed no difference in the abortion rate between the testicular sperm group and ejaculated sperm group (risk ratio: 1.06, 95% CI: 0.54–2.06, P = 0.87). The third meta-analysis of 386 cycles in seven studies showed no significant difference in clinical pregnancy rates between the testicular sperm group and the ejaculated sperm group (risk ratio: 1.24, 95% CI: 0.66–2.34, P = 0.50). Inevitable heterogeneity weakened our results. However, our results indicated that testicular sperm and ejaculated sperm yield similar ART outcomes, representing a meaningful result for clinical treatment. More properly designed studies are needed to further confirm our conclusions.
- Subjects :
- Adult
Male
endocrine system
Sperm Retrieval
Urology
medicine.medical_treatment
Sex Chromosome Disorders of Sex Development
assisted reproductive technology
azoospermia factor c microdeletions
ejaculated sperm
live birth rate
testicular sperm
Intracytoplasmic sperm injection
Andrology
medicine
Humans
Sperm Injections, Intracytoplasmic
Infertility, Male
Sex Chromosome Aberrations
reproductive and urinary physiology
Retrospective Studies
Azoospermia factor
Chromosomes, Human, Y
Assisted reproductive technology
urogenital system
business.industry
General Medicine
Spermatozoa
Sperm
Diseases of the genitourinary system. Urology
Confidence interval
Treatment Outcome
Relative risk
Meta-analysis
Original Article
RC870-923
Genetic Fitness
Chromosome Deletion
Live birth
business
Subjects
Details
- ISSN :
- 1008682X
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Asian Journal of Andrology
- Accession number :
- edsair.doi.dedup.....e41afc334fed9ce043c25d5888182279