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Long-term survival following upgrade compared with de novo cardiac resynchronization therapy implantation: a single-centre, high-volume experience
- Source :
- Europace
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- Aims Patients with a pacemaker or implantable cardioverter-defibrillator are often considered for cardiac resynchronization therapy (CRT). However, limited comprehensive data are available regarding their long-term outcomes. Methods and results Our retrospective registry included 2524 patients [1977 (78%) de novo, 547 (22%) upgrade patients] with mild to severe symptoms, left ventricular ejection fraction ≤35%, and QRS ≥ 130ms. The primary outcome was the composite of all-cause mortality, heart transplantation (HTX), or left ventricular assist device (LVAD) implantation; secondary endpoints were death from any cause and post-procedural complications. In our cohort, upgrade patients were older [71 (65–77) vs. 67 (59–73) years; P Conclusion In our retrospective analysis, upgrade patients had a higher risk of all-cause mortality than de novo patients, which might be attributable to their more significant comorbidity burden. The occurrence of lead dysfunction and pocket infections was more frequent in the upgrade group.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Cardiac resynchronization therapy
De novo CRT
Ventricular Function, Left
Upgrade
Clinical Research
Pacing and Cardiac Resynchronization Therapy
Physiology (medical)
Internal medicine
medicine
Risk of mortality
Humans
AcademicSubjects/MED00200
Cardiac Resynchronization Therapy Devices
Retrospective Studies
Heart Failure
Heart transplantation
Ejection fraction
Surrogate endpoint
business.industry
Hazard ratio
Stroke Volume
All-cause mortality
medicine.disease
Comorbidity
Defibrillators, Implantable
Treatment Outcome
Ventricular assist device
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Complication
Subjects
Details
- ISSN :
- 15322092 and 10995129
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- EP Europace
- Accession number :
- edsair.doi.dedup.....e44fc6c4181c60566f203f55dc68b727