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Preparation, characterization and feasibility study of dialdehyde carboxymethyl cellulose as a novel crosslinking reagent
- Source :
- Carbohydrate Polymers. 137:632-641
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- The natural biopolymers usually need to be chemically modified by crosslinking reagents to improve their mechanical properties. In the present research, the feasibility of using the dialdehyde carboxymethyl cellulose (DCMC) as a crosslinking reagent was systematically studied. DCMC was prepared by oxidizing carboxymethyl cellulose using sodium periodate. The formation of dialdehyde groups was confirmed by FTIR and the degree of oxidation was determined. The biocompatibility of DCMC was investigated by evaluating its cytotoxicity to L929 fibroblasts and histocompatibility in rat model via intramuscular and subcutaneous injection. DCMC-crosslinked carboxymethyl chitosan (DCMC-CMCTS) was prepared and characterized using the glutaraldehyde-crosslinked CMCTS (GA-CMCTS) as control. The result demonstrated that DCMC was non-cytotoxic, biodegradable and biocompatible. The DCMC-CMCTS displayed significantly better thermostability, swelling capacity and cyto-compatibility compared with GA-CMCTS. Our data provided experimental basis for the future application of DCMC as a novel crosslinking reagent.
- Subjects :
- Male
Polymers and Plastics
Biocompatibility
Molecular Sequence Data
macromolecular substances
02 engineering and technology
010402 general chemistry
01 natural sciences
Rats, Sprague-Dawley
chemistry.chemical_compound
Oxidizing agent
Materials Chemistry
medicine
Animals
Organic chemistry
Cellulose
Thermostability
Inflammation
Cytotoxins
Chemistry
Sodium periodate
Organic Chemistry
Swelling capacity
technology, industry, and agriculture
Fibroblasts
021001 nanoscience & nanotechnology
Rats
0104 chemical sciences
Carboxymethyl cellulose
Cross-Linking Reagents
Carbohydrate Sequence
Carboxymethylcellulose Sodium
Reagent
Microscopy, Electron, Scanning
Feasibility Studies
0210 nano-technology
medicine.drug
Subjects
Details
- ISSN :
- 01448617
- Volume :
- 137
- Database :
- OpenAIRE
- Journal :
- Carbohydrate Polymers
- Accession number :
- edsair.doi.dedup.....e4541fd13177fdb41bc7de66061ede48