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The association between KL polymorphism and prostate cancer risk in Korean patients
- Source :
- Molecular Biology Reports. 41:7595-7606
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- The Klotho (KL) gene is a classical “aging suppressor” gene. Although recent studies have shown that KL participates in the progression of several types of human cancers, the relationship between KL polymorphism and prostate cancer was unknown. The present study aimed to investigate the association between KL genetic polymorphisms and prostate cancer. Twenty-five common single nucleotide polymorphisms (SNPs) in KL gene (including KL gene polymorphism C1818T in exon 4) were assessed in 272 prostate cancer cases and 173 controls. Single-locus analyses were conducted using unconditional logistic regression. In addition, we did a haplotype analysis for the 25 KL SNPs tested. CC genotype of C1548T KL polymorphism had approximately twofold increased prostate cancer risk compared with the homozygous genotype TT and heterozygote CT (odds ratio 1.85 [95 % CI, 1.09–3.12], P = 0.02). We also found that non-T allele carriers had significantly higher prostate cancer risk associated with the prostate cancer clinical characteristics (tumor stage or Gleason score). Our findings suggested that the C1548T polymorphism of KL gene is associated with the prostate cancer and may act as a risk factor for the development of prostate cancer.
- Subjects :
- Male
Oncology
medicine.medical_specialty
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
Prostate cancer
Internal medicine
Republic of Korea
Genotype
Odds Ratio
Genetics
medicine
Humans
Allele
Klotho Proteins
Molecular Biology
Klotho
Genetic Association Studies
Aged
Glucuronidase
Haplotype
Prostatic Neoplasms
Heterozygote advantage
General Medicine
Odds ratio
Middle Aged
medicine.disease
Logistic Models
Haplotypes
Case-Control Studies
Immunology
Subjects
Details
- ISSN :
- 15734978 and 03014851
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Molecular Biology Reports
- Accession number :
- edsair.doi.dedup.....e47e5cb571b24cc9d7fa5a4362c008c1