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The effect of cardioprotective diet rich with natural antioxidants on chronic inflammation and oxidized LDL during cardiac rehabilitation in patients after acute myocardial infarction
- Source :
- International Journal of Cardiology. Heart & Vasculature, International Journal of Cardiology: Heart & Vasculature, Vol 7, Iss C, Pp 40-48 (2015), Scipedia Open Access, Scipedia SL
- Publication Year :
- 2017
-
Abstract
- Background Chronic inflammation, the fundamental pathogenetic process of atherosclerosis, can be modified by pharmacological and non-pharmacological measures as a part of secondary prevention after acute myocardial infarction (AMI). The aim of our study was to determine the effect of diet, rich with natural antioxidants, added to physical activity (as a part of cardiac rehabilitation (CR) program) on inflammatory markers and ox-LDL, a marker of oxidative stress, closely involved in the process of chronic inflammation. Methods 41 male patients after AMI undergoing CR were divided into a diet group (supervised cardioprotective diet throughout the CR), and control group (CR without diet). We measured hsCRP, leucocytes, neutrophils, IL-6, oxLDL, exercise capacity and classic risk factors before and after CR program. Results Patients from the diet group presented with a significant decline in classic risk factors (BMI, waist circumference, waist to hip ratio, systolic blood pressure, heart rate, blood glucose, total cholesterol, LDL, TAG) and inflammatory markers (hsCRP, leucocytes, neutrophils) compared to control group. Furthermore, when studying nonsmokers, we observed significant decline of oxLDL in the diet group. Conclusions The addition of cardioprotective diet, rich with natural antioxidants, to physical activity as a part of a CR program, positively modifies not just classic risk factors and exercise capacity, but also diminishes chronic inflammation markers. These effects, and oxLDL decline were most prominent in nonsmoking patients.
- Subjects :
- BP, blood pressure
Oxidized LDL
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Cardiac & Cardiovascular Systems
CAD, coronary artery disease
BMI, body mass index
Infarction
Cardiac rehabilitation
Inflammation
Acute myocardial infarction
medicine.disease_cause
Article
LDL, low density lipoprotein
Cardioprotective diet
Coronary artery disease
chemistry.chemical_compound
Waist–hip ratio
High-density lipoprotein
Internal medicine
hsCRP, high sensitivity CRP
Medicine
Myocardial infarction
oxLDL, oxidized LDL
business.industry
Smoking
medicine.disease
HDL, high density lipoprotein
CR, cardiac rehabilitation
Surgery
AMI, acute myocardial infarction
IL-6, interleukin 6
Endocrinology
Blood pressure
TAG, triglycerides
chemistry
lcsh:RC666-701
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Oxidative stress
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International Journal of Cardiology. Heart & Vasculature, International Journal of Cardiology: Heart & Vasculature, Vol 7, Iss C, Pp 40-48 (2015), Scipedia Open Access, Scipedia SL
- Accession number :
- edsair.doi.dedup.....e484a748bb296c1faef2ec1252140b01