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3′-Fluoro-3′-deoxy-5′-noraristeromycin derivatives: Synthesis and antiviral analysis
- Source :
- Bioorganic & Medicinal Chemistry. 14:4980-4986
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- The promising antiviral properties of 3'-fluoro-3'-deoxyadenosine and 4',4'-difluoro-4'-deoxy-5'-noraristeromycin prompted the synthesis of the corresponding 3'-fluoro derivatives of 5'-noraristeromycin. These target compounds, which were prepared from the same readily accessible cyclopentenol, were found to be inactive when subjected to 31 viral assays. The results have some implications on the mechanism of antiviral action of 5'-noraristeromycin and provide guidance for future geminal-difluoro analog design.
- Subjects :
- Adenosine
Chemistry
Stereochemistry
Organic Chemistry
Clinical Biochemistry
Pharmaceutical Science
Biological activity
Microbial Sensitivity Tests
Haloalcohol
In Vitro Techniques
Antiviral Agents
Biochemistry
Chemical synthesis
Structure-Activity Relationship
Drug Design
Viruses
Drug Discovery
Animals
Humans
Molecular Medicine
Noraristeromycin
Molecular Biology
Adenine derivatives
Subjects
Details
- ISSN :
- 09680896
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....e48e70ee17d93271517c2662b8606c8c