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Maternal glucose in pregnancy is associated with child's adiposity and leptin at 5 years of age
- Source :
- Pediatric Obesity. 16
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- BACKGROUND Exposure to maternal hyperglycaemia in pregnancy has been associated with childhood obesity. Leptin regulation might be involved in this 'adiposity programming' and may depend on timing of exposure. OBJECTIVES To investigate associations of maternal glycaemia at different periods in pregnancy with childhood adiposity and leptin levels at 5 years of age. METHODS In a prospective pre-birth cohort, we measured maternal glucose levels after a 50 g oral glucose challenge test at first trimester (9.8 ± 2.3 weeks) and during a 75 g oral glucose tolerance test at second trimester (26.5 ± 0.9 weeks). We followed up children at 5 years; we measured anthropometry and body composition using dual-energy X-ray absorptiometry (DXA). We measured fasting leptin levels using immunoassays (Luminex) in 328 children. We conducted linear regression analyses, adjusting for potential confounders. RESULTS Maternal glycaemia at first trimester was associated with childhood leptin levels at 5 years, independently of maternal pre-pregnancy BMI and other confounders (β = .09 ± .04; P = .03). Higher post-load glucose levels at second trimester were associated with greater total body fat percentage measured by DXA (1 hour-glucose: β = .010 ± .004; P = .03 and 2 hours-glucose: β = .016 ± .005; P = .002), but not with leptin levels. CONCLUSIONS Our results suggest that programming of leptin regulation may be sensitive to maternal hyperglycaemia specifically in early pregnancy.
- Subjects :
- Blood Glucose
Leptin
0301 basic medicine
Pediatric Obesity
Mothers
Physiology
030209 endocrinology & metabolism
Early pregnancy factor
Childhood obesity
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Pregnancy
medicine
Humans
Prospective Studies
Oral glucose tolerance
Adiposity
2. Zero hunger
030109 nutrition & dietetics
Nutrition and Dietetics
biology
business.industry
Health Policy
Confounding
Public Health, Environmental and Occupational Health
Anthropometry
medicine.disease
Child, Preschool
Prenatal Exposure Delayed Effects
Pediatrics, Perinatology and Child Health
Cohort
biology.protein
Birth Cohort
Female
business
Subjects
Details
- ISSN :
- 20476310 and 20476302
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Pediatric Obesity
- Accession number :
- edsair.doi.dedup.....e49a2b639586147d2456fb3cec9ba72e
- Full Text :
- https://doi.org/10.1111/ijpo.12788