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Daclatasvir plus Asunaprevir Treatment for Real-World HCV Genotype 1-Infected Patients in Japan
- Source :
- International Journal of Medical Sciences
- Publication Year :
- 2016
-
Abstract
- Background. All-oral combination of direct-acting antivirals could lead to higher sustained virologic response (SVR) in hepatitis C virus (HCV)-infected patients. In the present study, we examined the efficacy and safety of the dual oral treatment with HCV nonstructural protein (NS) 5A inhibitor daclatasvir (DCV) plus HCV NS3/4A inhibitor asunaprevir (ASV) for 24 weeks in real-world HCV genotype 1-infected Japanese individuals. Methods. After screening for HCV NS5A resistance-associated variants (RAVs) by PCR invader assay, a total of 54 Japanese patients infected with HCV genotype 1 treated with DCV plus ASV were retrospectively analyzed. SVR12 was used for evaluation of the virologic response. Results. Of the total 54 patients, 46 patients (85.2%) were treated with DCV plus ASV for 24 weeks and achieved SVR12. The other 8 patients (14.8%) discontinued this treatment before 24 weeks due to adverse events. Of these 8 patients, 5 and 3 patients did and did not achieve SVR12, respectively. Finally, 51 of 54 (94.4%) patients achieved SVR12. Conclusion. Treatment with DCV and ASV after screening for HCV NS5A RAVs by PCR invader assay is effective and safe in the treatment of real-world HCV genotype 1-infected patients in Japan.
- Subjects :
- Male
Oral treatment
Daclatasvir
Pyrrolidines
Genotype
Hepatitis C virus
Hepacivirus
Viral Nonstructural Proteins
medicine.disease_cause
Antiviral Agents
HCV NS5A
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Hcv genotype 1
Japan
Drug Resistance, Viral
Asunaprevir
Medicine
Humans
Adverse effect
NS5A
Resistance-associated variants
Aged
Retrospective Studies
Sulfonamides
business.industry
Imidazoles
virus diseases
Valine
General Medicine
Hepatitis C, Chronic
Middle Aged
Isoquinolines
Interferon-free
Virology
digestive system diseases
chemistry
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Drug Therapy, Combination
Female
Carbamates
business
medicine.drug
Research Paper
Subjects
Details
- ISSN :
- 14491907
- Volume :
- 13
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- International journal of medical sciences
- Accession number :
- edsair.doi.dedup.....e49c902c3a7822201488a3c6b103242c