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Modern Pathology Methods for Neural Investigations
- Source :
- Toxicologic Pathology. 39:52-57
- Publication Year :
- 2011
- Publisher :
- SAGE Publications, 2011.
-
Abstract
- This session at the 2010 joint symposium of the Society of Toxicologic Pathology (STP) and the International Federation of Societies of Toxicologic Pathologists (IFSTP) explored modern neuropathology methods for assessing the neurotoxicologic potential of xenobiotics. Conventional techniques to optimally prepare and evaluate the central and peripheral neural tissues while minimizing artifact were reviewed, and optimal schemes were set forth for evaluation of the nervous system during both routine (i.e., general toxicity) studies and enhanced (i.e., specialized neurotoxicity) studies. Stereology was introduced as the most appropriate means of examining the possible impact of toxicants on neural cell numbers. A focused discussion on brain sampling took place among a panel of expert neuroscientists (anatomists and pathologists) and the audience regarding the proper balance between sufficient sampling and cost- and time-effectiveness of the analysis. No consensus was reached on section orientation (coronal sections of both sides vs. a parasagittal longitudinal section with several unilateral hemisections from the contralateral side), but most panelists favored sampling at least 8 sections (or approximately double to triple the current complement) in routine toxicity studies.
- Subjects :
- Societies, Scientific
Pathology
medicine.medical_specialty
business.industry
Stereology
Cell Biology
Neuropathology
Congresses as Topic
Neural tissues
Toxicology
Nervous System
Xenobiotics
Pathology and Forensic Medicine
Evaluation Studies as Topic
Toxicity Tests
Animals
Humans
Medicine
Neurotoxicity Syndromes
Sampling (medicine)
Nervous System Diseases
business
Molecular Biology
Subjects
Details
- ISSN :
- 15331601 and 01926233
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Toxicologic Pathology
- Accession number :
- edsair.doi.dedup.....e4b8b9ef771308e82cf8e3293db174a4
- Full Text :
- https://doi.org/10.1177/0192623310394213