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Association of p16INK4a overexpression with improved outcomes in young patients with squamous cell cancers of the oral tongue
- Source :
- Head & Neck. 33:1622-1627
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- The aim of this study was to examine biomolecular profiles in a cohort of young adults with squamous cell cancers (SCCs) of the oral tongue.We identified all patients aged 18 to 39 years diagnosed with SCC of the oral tongue at our institution. Immunohistochemical (IHC) staining was performed for p16(INK4a) , epidermal growth factor receptor (EGFR), phosphorylated-EGFR (pEGFR), p53, and ERCC1. Human papillomavirus (HPV) testing was performed using in situ hybridization (ISH) and polymerase chain reaction (PCR). Biomarker expression and HPV status were correlated with outcomes.We identified 25 patients with sufficient tumor samples. Median age at diagnosis was 30 years (range, 20-39 years). p16(INK4a) overexpression was observed in 11 of 25 patients, whereas HPV-16 positivity was observed in none of the tumor samples by ISH and 2 of the tumor samples by PCR. p16(INK4a) positivity was correlated with improved relapse-free survival (hazard ratio [HR] = 0.23, p = .01) and overall survival (HR = 0.28, p = .05). Neither EGFR, pEGFR, p53, nor excision repair cross-complementing rodent repair deficiency, complementation group 1 (ERCC1) expression correlated with outcome on univariate analysis.p16(INK4a) overexpression was common and was a marker of favorable prognosis. p16(INK4a) overexpression was not a reliable predictor of HPV positivity in our cohort.
- Subjects :
- Male
Oncology
Pathology
Polymerase Chain Reaction
Cohort Studies
Epidermal growth factor receptor
Papillomaviridae
medicine.diagnostic_test
biology
Biopsy, Needle
Prognosis
Immunohistochemistry
Tongue Neoplasms
Gene Expression Regulation, Neoplastic
medicine.anatomical_structure
Carcinoma, Squamous Cell
Biomarker (medicine)
Female
Adult
medicine.medical_specialty
Adolescent
Risk Assessment
Disease-Free Survival
Statistics, Nonparametric
Young Adult
Tongue
Internal medicine
Biopsy
Biomarkers, Tumor
medicine
Carcinoma
Humans
Serologic Tests
Neoplasm Staging
Proportional Hazards Models
Retrospective Studies
Analysis of Variance
business.industry
Genes, p16
Papillomavirus Infections
Head and neck cancer
medicine.disease
Survival Analysis
Otorhinolaryngology
DNA, Viral
biology.protein
Neoplasm Recurrence, Local
ERCC1
business
Subjects
Details
- ISSN :
- 10433074
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Head & Neck
- Accession number :
- edsair.doi.dedup.....e4cd364e51a2363352cc6555072c7875