Back to Search
Start Over
Structural investigation of proapoptotic peptide by CD and NMR spectroscopy
- Source :
- Protein and peptide letters. 10(6)
- Publication Year :
- 2003
-
Abstract
- We have performed a systematic investigation of the structural features of the peptides Int (a sequence able to cross cell membranes) and Int-H1(S6A,F8A) (which shows interesting antitumoral properties). After screening in aqueous solution at different ionic strength and pH values, we analyzed the structures of the peptides in different water / trifluoroethanol mixtures by Circular Dichroism and Nuclear Magnetic Resonance techniques.
- Subjects :
- Circular dichroism
Magnetic Resonance Spectroscopy
Protein Conformation
Molecular Sequence Data
Sequence (biology)
Peptide
Antineoplastic Agents
Apoptosis
Biochemistry
Protein Structure, Secondary
Proto-Oncogene Proteins c-myc
Structural Biology
Proto-Oncogene Proteins
Amino Acid Sequence
chemistry.chemical_classification
Aqueous solution
Circular Dichroism
Water
General Medicine
Nuclear magnetic resonance spectroscopy
Trifluoroethanol
Hydrogen-Ion Concentration
Solutions
Wnt Proteins
Crystallography
Membrane
chemistry
Ionic strength
Drug Design
Peptides
Subjects
Details
- ISSN :
- 09298665
- Volume :
- 10
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Protein and peptide letters
- Accession number :
- edsair.doi.dedup.....e4d1bd1036c2a4e86b4a80d8e6e308e5