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Ambient air pollution, adipokines, and glucose homeostasis: The Framingham Heart Study
- Source :
- Environment International, Vol 111, Iss, Pp 14-22 (2018)
- Publication Year :
- 2017
-
Abstract
- Objective: To examine associations of proximity to major roadways, sustained exposure to fine particulate matter (PM2.5), and acute exposure to ambient air pollutants with adipokines and measures of glucose homeostasis among participants living in the northeastern United States. Methods: We included 5958 participants from the Framingham Offspring cohort examination cycle 7 (1998–2001) and 8 (2005–2008) and Third Generation cohort examination cycle 1 (2002–2005) and 2 (2008–2011), who did not have type 2 diabetes at the time of examination visit. We calculated 2003 annual average PM2.5 at participants' home address, residential distance to the nearest major roadway, and daily PM2.5, black carbon (BC), sulfate, nitrogen oxides (NOx), and ozone concentrations. We used linear mixed effects models for fasting glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) which were measured up to twice, and used linear regression models for adiponectin, resistin, leptin, and hemoglobin A1c (HbA1c) which were measured only once, adjusting for demographics, socioeconomic position, lifestyle, time, and seasonality. Results: The mean age was 51years and 55% were women. Participants who lived 64m (25th percentile) from a major roadway had 0.28% (95% CI: 0.05%, 0.51%) higher fasting plasma glucose than participants who lived 413m (75th percentile) away, and the association appeared to be driven by participants who lived within 50m from a major roadway. Higher exposures to 3- to 7-day moving averages of BC and NOx were associated with higher glucose whereas the associations for ozone were negative. The associations otherwise were generally null and did not differ by median age, sex, educational attainment, obesity status, or prediabetes status. Conclusions: Living closer to a major roadway or acute exposure to traffic-related air pollutants were associated with dysregulated glucose homeostasis but not with adipokines among participants from the Framingham Offspring and Third Generation cohorts. Keywords: Air pollution, Adipokines, Glucose homeostasis, Epidemiology, Particulate matter
- Subjects :
- Adult
Male
Adipokine
Type 2 diabetes
030204 cardiovascular system & hematology
010501 environmental sciences
01 natural sciences
Article
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Framingham Heart Study
Insulin resistance
Ozone
Adipokines
Soot
Air Pollution
medicine
Glucose homeostasis
Homeostasis
Humans
Prediabetes
lcsh:Environmental sciences
0105 earth and related environmental sciences
General Environmental Science
Aged
Vehicle Emissions
lcsh:GE1-350
Glycated Hemoglobin
Air Pollutants
Framingham Risk Score
business.industry
Sulfates
Middle Aged
medicine.disease
Glucose
Cohort
Housing
Linear Models
Female
Nitrogen Oxides
Particulate Matter
business
Demography
Environmental Monitoring
Subjects
Details
- ISSN :
- 18736750
- Volume :
- 111
- Database :
- OpenAIRE
- Journal :
- Environment international
- Accession number :
- edsair.doi.dedup.....e51afd206d4649b9d83ad3d5a4e0474d