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Enhanced Bioactivity of Pomegranate Peel Extract following Controlled Release from CaCO3 Nanocrystals

Authors :
Francesco Paolo Fanizzi
Giuseppe Ciccarella
Domenico Rongai
Gian Paolo SURANNA
Federica De Castro
Paride Papadia
Francesca Baldassarre
Francesca Biondo
Viviana Vergaro
Baldassarre, Francesca
Vergaro, Viviana
DE CASTRO, Federica
Biondo, Francesca
Suranna, Gian Paolo
Papadia, Paride
Fanizzi, Francesco P.
Rongai, Domenico
Ciccarella, Giuseppe
Source :
Bioinorganic Chemistry and Applications. 2022:1-16
Publication Year :
2022
Publisher :
Hindawi Limited, 2022.

Abstract

Pomegranate peel extract is rich of interesting bioactive chemicals, principally phenolic compounds, which have shown antimicrobial, anticancer, and antioxidative properties. The aim of this work was to improve extract’ bioactivity through the adsorption on calcium carbonate nanocrystals. Nanocrystals revealed as efficient tools for extract adsorption reaching 50% of loading efficiency. Controlled release of the contained metabolites under acidic pH has been found, as it was confirmed by quantitative assay and qualitative study through NMR analysis. Specific functionality of inorganic nanocarriers could be also tuned by biopolymeric coating. The resulting coated nanoformulations showed a great antimicrobial activity against B. cinerea fungus preventing strawberries disease better than a commercial fungicide. Furthermore, nanoformulations demonstrated a good antiproliferative activity in neuroblastoma and breast cancer cells carrying out a higher cytotoxic effect respect to free extract, confirming a crucial role of nanocarriers. Finally, pomegranate peel extract showed a very high radical scavenging ability, equal to ascorbic acid. Antioxidant activity, measured also in intracellular environment, highlighted a protective action of extract-adsorbed nanocrystals twice than free extract, providing a possible application for new nutraceutical formulations.

Details

ISSN :
1687479X and 15653633
Volume :
2022
Database :
OpenAIRE
Journal :
Bioinorganic Chemistry and Applications
Accession number :
edsair.doi.dedup.....e529664ccb819026c3add647697347cb
Full Text :
https://doi.org/10.1155/2022/6341298