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Ataxia Telangiectasia-Mutated (ATM)Polymorphisms and Risk of Lung Cancer in a Chinese Population
- Source :
- Frontiers in Public Health, Vol 5 (2017)
- Publication Year :
- 2017
- Publisher :
- Frontiers Media SA, 2017.
-
Abstract
- Background The ataxia telangiectasia-mutated (ATM) gene has a key role in DNA repair including activation and stabilization of p53, which implicates the importance of ATM polymorphisms in the development of cancer. This study aims to investigate the association of two ATM single-nucleotide polymorphisms (SNPs) with lung cancer, as well as their potential interaction with p53 gene and other known risk factors of lung cancer. Methods A population-based case–control study was conducted in Taiyuan city, China with 399 cases and 466 controls matched on the distribution of age and sex of cases. The two ATM gene SNPs, ATMrs227060 and ATMrs228589 as well as p53 gene SNP, p53rs1042522 were genotyped using Sequenom platform. Unconditional logistic regression models were used to estimate crude and adjusted odds ratios (aOR) and 95% confidence intervals (CIs). Adjusted models controlled for age, sex, and smoking status. Results The study showed that TT genotype of ATMrs227060 (aOR = 1.58, 95% CI: 1.06–2.35) and AA genotype of ATMrs228589 were significantly associated with lung cancer (aOR = 1.50, 95% CI: 1.08–2.08) in a recessive model. Additionally, carrying variant genotypes of ATMrs227060 (TT), ATMrs228589 (AA), and p53rs1042522 (CC) concomitantly was associated with much higher risk (aOR = 3.68, 95% CI: 1.43–9.45) of lung cancer than carrying variant genotypes of any one of the above three SNPs. We also found multiplicative and additive interaction between tea drinking and ATMrs227060 in association with lung cancer. Conclusion This study indicates that ATM gene variants might be associated with development of lung cancer in Chinese population. These results need to be validated in larger and different population samples.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Population
DNA repair
Single-nucleotide polymorphism
Neurodegenerative
Biology
Bioinformatics
ataxia telangiectasia-mutated gene
Ataxia Telangiectasia
03 medical and health sciences
Rare Diseases
0302 clinical medicine
Internal medicine
single-nucleotide polymorphisms
Genotype
Genetics
medicine
2.1 Biological and endogenous factors
SNP
Aetiology
education
Lung cancer
Lung
Cancer
education.field_of_study
lcsh:Public aspects of medicine
Prevention
Lung Cancer
Public Health, Environmental and Occupational Health
lcsh:RA1-1270
Odds ratio
medicine.disease
Confidence interval
3. Good health
lung cancer
030104 developmental biology
030220 oncology & carcinogenesis
Public Health and Health Services
Public Health
Chinese population
Subjects
Details
- ISSN :
- 22962565
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Frontiers in Public Health
- Accession number :
- edsair.doi.dedup.....e57d43048ba81dadd50d31c219e437be