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The effect of postmastectomy radiotherapy in node-positive triple-negative breast cancer
- Source :
- BMC Cancer
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Background The value of postmastectomy radiotherapy (PMRT) for pathological node-positive triple-negative breast cancers (TNBC) remains debatable. The aim of this population-based retrospective study was to evaluate the effect of PMRT on survival outcomes in this population. Methods Patients diagnosed with stage T1-4N1-N3M0 TNBC between 2010 and 2014 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. We used univariate and multivariate Cox regression hazards method to determine the independent prognostic factors associated with 3-year breast cancer-specific survival (BCSS). The effect of PMRT on 3-year BCSS was analyzed after stratification by pathological staging of groups. Results Of the 4398 patients included in this study, 2649 (60.2%) received PMRT. Younger age, black ethnicity, and advanced tumor (T) and nodal (N) stage were the independent predictors associated with PMRT receipt (all P P P = 0.042), T1-4N2 (P P P = 0.191). Conclusions Radiotherapy achieved better 3-year BCSS in TNBC patients with stage T3–4N1 and T1-4N2–3 disease. However, no survival benefit was found with the addition of PMRT in patients with T1–2N1 TNBC.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Survival
Pathological staging
medicine.medical_treatment
Population
Triple Negative Breast Neoplasms
Database
03 medical and health sciences
Breast cancer
0302 clinical medicine
Surgical oncology
Internal medicine
Genetics
Humans
Medicine
030212 general & internal medicine
education
Mastectomy
Triple-negative breast cancer
Retrospective Studies
education.field_of_study
business.industry
Proportional hazards model
Carcinoma, Ductal, Breast
Radiotherapy treatment
Retrospective cohort study
Middle Aged
Prognosis
medicine.disease
Survival Rate
Radiation therapy
Carcinoma, Lobular
030220 oncology & carcinogenesis
Female
Radiotherapy, Adjuvant
business
Follow-Up Studies
SEER Program
Subjects
Details
- ISSN :
- 14712407
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.doi.dedup.....e58723ef04a0fe5736296c433630e48e