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Hybrid Nanosystems Based on Nicotinate-Functionalized Mesoporous Silica and Silver Chloride Nanoparticles Loaded with Phenytoin for Preventing Pseudomonas aeruginosa Biofilm Development

Hybrid Nanosystems Based on Nicotinate-Functionalized Mesoporous Silica and Silver Chloride Nanoparticles Loaded with Phenytoin for Preventing Pseudomonas aeruginosa Biofilm Development

Authors :
Maider Ugalde-Arbizu
John Jairo Aguilera-Correa
Aranzazu Mediero
Jaime Esteban
Paulina L. Páez
Eider San Sebastian
Santiago Gómez-Ruiz
Source :
Addi. Archivo Digital para la Docencia y la Investigación, instname, Pharmaceuticals; Volume 15; Issue 7; Pages: 884
Publication Year :
2022
Publisher :
MDPI, 2022.

Abstract

Pseudomonas aeruginosa (PA) is one of the most common bacteria isolated from chronic wounds and burns. Its treatment is a challenge due to antimicrobial drug resistance and biofilm formation. In this context, this study aimed to perform the synthesis and full characterization of hybrid nanosystems based on mesoporous silica nanoparticles (MSNs) functionalized with a nicotinic ligand and silver chloride nanoparticles, both phenytoin sodium (Ph)-loaded and unloaded, to evaluate the antibacterial properties against three different strains of PA (including two clinical strains) in a planktonic state and as biofilms. Ph is a well-known proliferative agent, which was incorporated into the hybrid nanomaterials to obtain an effective material for tissue healing and prevention of infection caused by PA. The Ph-loaded materials promoted a quasi-complete inhibition of bacterial growth in wound-like medium and biofilm development, with values of 99% and 96%, respectively, with selectivity indices above the requirements for drugs to become promising agents for the topic preventive treatment of chronic wounds and burns. We would like to thank funding from Agencia Estatal de Investigación—Ministerio de Ciencia e Innovación of Spain and FEDER Una Manera de Hacer Europa for the grant RTI2018-094322- B-I00 and the University of the Basque Country UPV/EHU (GIC18/143). A.M. was funded by grants from Instituto de Salud Carlos III through the “Miguel Servet” program (CP15/00053)

Details

Database :
OpenAIRE
Journal :
Addi. Archivo Digital para la Docencia y la Investigación, instname, Pharmaceuticals; Volume 15; Issue 7; Pages: 884
Accession number :
edsair.doi.dedup.....e5ca3337dba033b8aeacc877e8738038