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Triple negative breast cancer: From molecular portrait to therapeutic intervention
- Source :
- Scopus-Elsevier
- Publication Year :
- 2010
-
Abstract
- Triple negative breast cancer is a subtype of breast cancer that lacks expression of an estrogen receptor (ER), a progesterone receptor (PR), and HER2. It is characterized by its unique molecular profile, aggressive behavior, and distinct pattern of metastasis. Epidemiological studies show a high prevalence of triple negative breast cancer among younger women and those of African descent. Although sensitive to chemotherapy, early relapse is common, and a predilection for visceral metastasis, including brain metastasis, has been described. Gene-expression profiling approaches demonstrated that triple negative breast cancer is a heterogeneous group of diseases composed of different, molecularly distinct subtypes. Although not synonymous, the majority of triple negative breast cancers carry the "basal-like" molecular profile on gene-expression arrays. However, several studies have shown that triple negative breast cancer includes tumors with a non-basal expression profile and, in particular, the "normal-breast," the "multiple marker negative," and the recently identified "claudin-negative" subtypes. Target-based agents, including epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and poly-ADP-ribose polymerase (PARP) inhibitors, are currently in clinical trials and hold promise in the treatment of this aggressive disease. © 2010 by Begell House, Inc.
- Subjects :
- Receptor, ErbB-2
Estrogen receptor
Breast Neoplasms
Target therapy
Metastasis
chemistry.chemical_compound
Breast cancer
Progesterone receptor
Genetics
Medicine
Humans
Epidermal growth factor receptor
Molecular Biology
Triple-negative breast cancer
Comparative Genomic Hybridization
biology
business.industry
Gene Expression Profiling
Chromosome Mapping
Genes, erbB-2
medicine.disease
Molecular portrait
Vascular endothelial growth factor
Gene Expression Regulation, Neoplastic
chemistry
Receptors, Estrogen
Cancer research
biology.protein
Neoplastic Stem Cells
Female
Gene expression
Neoplastic Stem Cell
business
Triple negative
Receptors, Progesterone
Breast Neoplasm
Brain metastasis
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....e5cd2e06561dd9544bd1352efcbabf31