Back to Search
Start Over
Safety of bronchoscopy in patients with malignant hematologic disorders
- Source :
- BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-6 (2020), BMC Pulmonary Medicine
- Publication Year :
- 2020
- Publisher :
- Research Square Platform LLC, 2020.
-
Abstract
- Background Factors affecting the safety of bronchoscopy in patients with malignant hematologic disorders have not been well described. We evaluated the safety of bronchoscopy and describe factors affecting its complication rate in such patients. Methods Between January 2009 and December 2018, 316 bronchoscopies in 282 patients with malignant hematologic disorders and pulmonary infiltrates were performed at our institution. The bronchoscopic procedure used and its complications were evaluated. Results The most common underlying disease was acute myeloid leukemia (134/282 patients, 47.5%). Platelet transfusion was performed the day before or the day of bronchoscopy in 42.4%, supplemental oxygen was administered before the procedure in 23.1%, and midazolam was used in 74.4%. Thirty-five bronchoscopies (11.1%) were complicated by hemoptysis and 7 patients developed pneumothorax, 4 of whom required thoracic drainage. Two patients (0.6%) were intubated within 48 h of the procedure and prolonged oxygen desaturation (> 48 h) occurred in 3.8%. Multivariate analysis showed that only use of midazolam significantly reduced the risk of prolonged oxygen desaturation (hazard ratio 0.28, 95% confidence interval 0.09–0.85, p = 0.03). Transbronchial lung biopsy significantly increased the risk of hemoptysis (hazard ratio 10.40, 95% confidence interval 4.18–25.90, p = 0.00), while use of midazolam significantly reduced the risk (hazard ratio 0.31, 95% confidence interval 0.14–0.73, p = 0.01). Conclusions Bronchoscopy is relatively safe in patients with malignant hematologic disorders. Caution and judicious use of sedatives may improve the patient’s procedural tolerance and lower complications.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
Midazolam
medicine.medical_treatment
Hematopoietic stem cell transplantation
Bronchoscopies
03 medical and health sciences
Postoperative Complications
0302 clinical medicine
Bronchoscopy
medicine
Humans
Aged
Retrospective Studies
lcsh:RC705-779
Acute myeloid leukemia
medicine.diagnostic_test
business.industry
Malignant lymphoma
Hazard ratio
lcsh:Diseases of the respiratory system
Middle Aged
medicine.disease
Confidence interval
Platelet transfusion
030228 respiratory system
Pneumothorax
Hematologic Neoplasms
030220 oncology & carcinogenesis
Anesthesia
Female
business
Myelodysplastic syndrome
Research Article
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-6 (2020), BMC Pulmonary Medicine
- Accession number :
- edsair.doi.dedup.....e5ea1df633ce67c42e79f286240c4fda