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Effects of nimodipine combined with betahistine on CRP and other inflammatory cytokines and vascular endothelial function in patients with hypertensive cerebral vasospasm
- Source :
- Clinical Hemorheology and Microcirculation. 75:279-289
- Publication Year :
- 2020
- Publisher :
- IOS Press, 2020.
-
Abstract
- OBJECTIVE: This study aims to investigate the effect of nimodipine combined with betahistine on the levels of CRP and other inflammatory cytokines, as well as vascular endothelial function in patients with hypertensive cerebral vasospasm. METHODS: A total of 80 patients with hypertensive cerebral vasospasm from March 2016 to September 2018 were enrolled and randomly equally divided into two groups. At 1 week before enrollment, the application of all antihypertensive drugs was stopped. Then amlodipine tablets were used in control group, based on which nimodipine tablets were applied in observation group. All the patients included were followed up for 1 month. The changes in the cerebral vasospasm index in the course of treatment as well as inflammatory cytokines and indicators related to vascular endothelial function at 1 month after treatment were measured and compared between the two groups. The correlations of the cerebral vasospasm index with the changes in inflammatory cytokines and vascular endothelial function-related factors in the body were analyzed. Finally, the effective rates of blood pressure regulation and cerebral vasospasm treatment were compared, while the adverse reactions and the overall clinical treatment effect of the two groups were evaluated. RESULTS: The cerebral vasospasm indexes in observation group were significantly lower than those in control group at 3 d, 1 week and 1 month after treatment (p 0.05). CONCLUSION: For the treatment of hypertensive cerebral vasospasm, combined application of betahistine on the basis of nimodipine can effectively reduce the body’s aseptic inflammatory responses, improve vascular endothelial function and increase the cerebral circulation blood flow, which offers a favorable strategy for clinical therapy.
- Subjects :
- Male
medicine.medical_specialty
Physiology
Vasodilator Agents
030204 cardiovascular system & hematology
030218 nuclear medicine & medical imaging
Proinflammatory cytokine
03 medical and health sciences
Cerebral circulation
0302 clinical medicine
Cerebral vasospasm
Physiology (medical)
Internal medicine
medicine
Humans
Vasospasm, Intracranial
Betahistine
Amlodipine
Nimodipine
Antihypertensive Agents
Aged
business.industry
Hematology
Blood flow
Middle Aged
C-Reactive Protein
Blood pressure
Hypertension
Cardiology
Cytokines
Female
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 18758622 and 13860291
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Clinical Hemorheology and Microcirculation
- Accession number :
- edsair.doi.dedup.....e5ee40850388b77edbec9af801c5f644