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The role of rs242941, rs1876828, rs242939 and rs110402 polymorphisms of CRHR1 gene and the depression: systematic review and meta-analysis
- Source :
- Genes & Genomics. 43:1339-1349
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Several studies have evaluated the possible association between polymorphisms or variants in Corticotropin-releasing hormone 1 receptor gene (CRHR1) with depression; however, results remain contradictory and heterogeneous. To our knowledge, we conducted the first comprehensive systematic review and meta-analysis evaluating the association of the CRHR1 gene and the risk of depression. A search online was conducted in databases for any CRHR1 genetic association studies in depression. Data were extracted for evaluation of pooled estimates using meta-analytic techniques. Statistical analyses were performed using the Comprehensive Meta-analysis, v2.0 software. A total of 1403 cases and 2353 mentally healthy controls were included in this study. We found a significant association of rs242941, rs1876828 and rs242939 variants of the CRHR1 gene with depression. No association of CRHR1 rs110402 and depression was observed. Our meta-analysis shows that some variants of the CRHR1 gene (rs242941, rs1876828 and rs242939) might confer susceptibility to depression. Further studies with larger sample sizes need to be conducted.
- Subjects :
- Databases, Factual
Genotype
Depression
Biology
Bioinformatics
Polymorphism, Single Nucleotide
Receptors, Corticotropin-Releasing Hormone
Biochemistry
Human genetics
Genetic Heterogeneity
Sample size determination
Meta-analysis
Statistical analyses
Genetics
Humans
Genetic Predisposition to Disease
CRHR1 Gene
Molecular Biology
Gene
Depression (differential diagnoses)
Genetic association
Subjects
Details
- ISSN :
- 20929293 and 19769571
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Genes & Genomics
- Accession number :
- edsair.doi.dedup.....e5fbb9f9c925e9767016a0ad5c8ee9ac