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Cobalt chloride exposure dose-dependently induced hepatotoxicity through enhancement of cyclooxygenase-2 (COX-2)/B-cell associated protein X (BAX) signaling and genotoxicity in Wistar rats
- Source :
- Environmental toxicology. 32(7)
- Publication Year :
- 2016
-
Abstract
- Cobalt chloride (CoCl2 ) is one of the many environmental contaminants, used in numerous industrial sectors. It is a pollutant with deadly toxicological consequences both in developing and developed countries. We investigated toxicological impact of CoCl2 on hepatic antioxidant status, apoptosis, and genotoxicity. Forty Wistar rats were divided into four groups, 10 rats per group: Group 1 served as control and received clean tap water orally; Group 2 received CoCl2 solution (150 mg/L); Group 3 received CoCl2 solution (300 mg/L); and Group 4 received CoCl2 (600 mg/L) in drinking water for 7 days, respectively. Exposure of rats to CoCl2 led to a significant decline in hepatic antioxidant enzymes together with significant increase in markers of oxidative stress. Immunohistochemistry revealed dose-dependent increase in cyclooxygenase-2 and BAX expressions together with increased frequency of Micronucleated Polychromatic Erythrocytes. Combining all, CoCl2 administration led to hepatic damage through induction of oxidative stress, inflammation, and apoptosis.
- Subjects :
- 0301 basic medicine
Male
Antioxidant
Erythroblasts
Health, Toxicology and Mutagenesis
medicine.medical_treatment
Inflammation
Apoptosis
010501 environmental sciences
Management, Monitoring, Policy and Law
Pharmacology
Toxicology
medicine.disease_cause
01 natural sciences
Antioxidants
03 medical and health sciences
medicine
Animals
Rats, Wistar
0105 earth and related environmental sciences
bcl-2-Associated X Protein
chemistry.chemical_classification
biology
General Medicine
Cobalt
Oxidative Stress
030104 developmental biology
Enzyme
chemistry
Cyclooxygenase 2
Micronucleus test
biology.protein
Environmental Pollutants
Cyclooxygenase
medicine.symptom
Chemical and Drug Induced Liver Injury
Genotoxicity
Oxidative stress
DNA Damage
Mutagens
Signal Transduction
Subjects
Details
- ISSN :
- 15227278
- Volume :
- 32
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Environmental toxicology
- Accession number :
- edsair.doi.dedup.....e60f63c64729f512d7e462bbe83012aa