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Helicobacter pylori infection is associated with worse severity of Parkinson's disease
- Source :
- Parkinsonism & Related Disorders. 21:221-225
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Background Some studies have suggested that chronic Helicobacter pylori (HP) infection can aggravate the neurodegenerative process in Parkinson's disease (PD), and targeted intervention could potentially modify the course of this disabling disease. We aimed to study the impact of HP infection on motor function, gastrointestinal symptoms, and quality of life in a large cohort of PD patients. Methods 102 consecutive PD patients underwent 13 C urea breath testing and blinded evaluations consisting of the Unified Parkinson's Disease Rating Scale (UPDRS) including “On”-medication motor examination (Part III), objective and quantitative measures of bradykinesia (Purdue Pegboard and timed gait), Leeds Dyspepsia Questionnaire, and PDQ-39 (a health-related quality of life questionnaire). Results 32.4% of PD patients were HP-positive. HP-positive patients were older (68.4 ± 7.3 vs. 63.8 ± 8.6 years, P = 0.009) and had worse motor function (UPDRS Part III 34.0 ± 13.0 vs. 27.3 ± 10.0, P = 0.04; Pegboard 6.4 ± 3.3 vs. 8.0 ± 2.7 pins, P = 0.04; and timed gait 25.1 ± 25.4 vs. 15.5 ± 7.6 s, P = 0.08). In the multivariate analysis, HP status demonstrated significant main effects on UPDRS Part III and timed gait. The association between HP status and these motor outcomes varied according to age. Gastrointestinal symptoms and PDQ-39 Summary Index scores did not differ between the two groups. Conclusions This is the largest cross-sectional study to demonstrate an association between HP positivity and worse PD motor severity.
- Subjects :
- Male
Helicobacter pylori infection
medicine.medical_specialty
Parkinson's disease
Multivariate analysis
Spectrophotometry, Infrared
Disease
Severity of Illness Index
Gastroenterology
Statistics, Nonparametric
Helicobacter Infections
Quality of life
Predictive Value of Tests
Rating scale
Surveys and Questionnaires
Internal medicine
Humans
Medicine
Aged
Aged, 80 and over
Helicobacter pylori
biology
business.industry
Age Factors
Parkinson Disease
Middle Aged
medicine.disease
biology.organism_classification
Gait
Breath Tests
Neurology
Quality of Life
Female
Neurology (clinical)
Geriatrics and Gerontology
business
Subjects
Details
- ISSN :
- 13538020
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Parkinsonism & Related Disorders
- Accession number :
- edsair.doi.dedup.....e61afd4598e7a19a7eb8c49c50b851df