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Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity
- Source :
- Nutrition, metabolism, and cardiovascular diseases : NMCD. 26(11)
- Publication Year :
- 2016
-
Abstract
- Obesity is increasing worldwide and is related to undesirable cardiovascular outcomes. Epicardial fat (EF), the heart visceral fat depot, increases with obesity and correlates with cardiovascular risk. SIRT1, an enzyme regulating metabolic circuits linked with obesity, has a cardioprotective effect and is a predictor of cardiovascular events. We aimed to assess the relationship of EF thickness (EFT) with circulating SIRT1 in patients with obesity.Sixty-two patients affected by obesity and 23 lean controls were studied. Plasma SIRT1 concentration was determined by enzyme-linked immunosorbent assay (ELISA). EFT was measured by echocardiography. Body mass index (BMI), waist circumference, heart rate (HR), blood pressure, and laboratory findings (fasting glucose, insulin, HbA1c, cholesterol, and triglycerides) were assessed. SIRT1 was significantly lower (P = 0.002) and EFT was higher (P 0.0001) in patients with obesity compared with lean controls. SIRT1 showed a negative correlation with EFT and HR in the obesity group (ρ = -0.350, P = 0.005; ρ = -0.303, P = 0.008, respectively). After adjustment for obesity-correlated variables, multiple linear regression analysis showed that EFT remained the best correlate of SIRT1 (β = -0.352, P = 0.016).Circulating SIRT1 correlates with the visceral fat content of the heart. Serum SIRT1 levels might provide additional information for risk assessment of coronary artery disease in patients with obesity.
- Subjects :
- Adult
Male
medicine.medical_specialty
Waist
Intra-Abdominal Fat
Adolescent
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
030209 endocrinology & metabolism
Enzyme-Linked Immunosorbent Assay
Coronary Artery Disease
030204 cardiovascular system & hematology
Risk Assessment
Epicardial fat
Obesity
SIRT1
Coronary artery disease
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
Sirtuin 1
Risk Factors
Internal medicine
Heart rate
medicine
Humans
Adiposity
Aged
Nutrition and Dietetics
business.industry
Cholesterol
Middle Aged
medicine.disease
Echocardiography, Doppler
Endocrinology
Blood pressure
chemistry
Case-Control Studies
Multivariate Analysis
Linear Models
Female
Cardiology and Cardiovascular Medicine
business
Body mass index
Pericardium
Biomarkers
Subjects
Details
- ISSN :
- 15903729
- Volume :
- 26
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Nutrition, metabolism, and cardiovascular diseases : NMCD
- Accession number :
- edsair.doi.dedup.....e6256ba19df8b81bf210e897ebdef977