Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-Barré syndrome

Authors :: Leonard H. van den Berg
Anne P Tio-Gillen
W-Ludo van der Pol
Elisabeth A. Cats
Bart C. Jacobs
Frank P. Diekstra
Immunology
Neurology
Source :: Journal of Neurology Neurosurgery and Psychiatry, 86(5), 502-504. BMJ Publishing Group, Journal of Neurology, Neurosurgery and Psychiatry, 86(5), 502. BMJ Publishing Group
Publication Year :: 2014
Abstract: Objective Multifocal motor neuropathy ( MMN) and the Guillain-Barre syndrome ( GBS) are immune-mediated motor neuropathies with antibodies against the ganglioside GM1. In GBS, these antibodies are induced by molecular mimicry, but in MMN their origin is elusive. Methods We compared the light-chain use of anti-GM1 IgM antibodies in serum from 42 patients with MMN and 23 patients with GBS by ELISA. Results Exclusive use of either. or. light chains was found in 38 ( 90%) patients with MMN and 9 ( 39%) with GBS ( p

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