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Seizures and Sepsis: A Narrative Review
- Source :
- Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 10, Iss 1041, p 1041 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Patients with sepsis-associated encephalopathy (SAE) can develop convulsive or nonconvulsive seizures. The cytokine storm and the overwhelming systemic inflammation trigger the electric circuits that promote seizures. Several neurologic symptoms, associated with this disease, range from mild consciousness impairment to coma. Focal or generalized convulsive seizures are frequent in sepsis, although nonconvulsive seizures (NCS) are often misdiagnosed and prevalent in SAE. In order to map the trigger zone in all patients that present focal or generalized seizures and also to detect NCS, EEG is indicated but continuous EEG (cEEG) is not very widespread; timing, duration, and efficacy of this tool are still unknown. The long-term risk of seizures in survivors is increased. The typical stepwise approach of seizures management begins with benzodiazepines and follows with anticonvulsants up to anesthetic drugs such as propofol or thiopental, which are able to induce burst suppression and interrupt the pathological electrical circuits. This narrative review discusses pathophysiology, clinical presentation, diagnosis and treatment of seizures in sepsis.
- Subjects :
- Encephalopathy
lcsh:Medicine
Review
Electroencephalography
Systemic inflammation
Sepsis
03 medical and health sciences
0302 clinical medicine
medicine
seizures
Coma
septic encephalopathy
medicine.diagnostic_test
business.industry
lcsh:R
030208 emergency & critical care medicine
General Medicine
medicine.disease
cEEG
Burst suppression
Anesthesia
Anticonvulsants
CEEG
Seizures
Septic encephalopathy
anticonvulsants
medicine.symptom
Propofol
Cytokine storm
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 10
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....e63858fcbfa8a7eab4e183cfa55c8594