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Re‐evaluation of the prognostic significance of retropharyngeal node metastasis in nasopharyngeal carcinoma patients treated with intensity‐modulated radiotherapy
- Source :
- Asia-Pacific Journal of Clinical Oncology. 18
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- BACKGROUND AND PURPOSE To investigate the prognostic value of retropharyngeal lymphadenopathy in nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy. MATERIALS AND METHODS Retrospective studies were performed in a total of 1197 patients. We evaluated the incidence of the retropharyngeal node (RPN) metastasis and the characteristics of the metastatic RPN including laterality, size, necrosis, and extranodal neoplastic spread. RESULTS RPN metastasis occured in 86.3% of patients. The RPN and level II metastasis shared similar survival outcomes. RPN metastasis was an independent prognostic factor for distant failure (hazard ratio = 1.615; 95% confidence interval, 1.063-2.452; P = 0.025), in which the laterality of RPN metastasis significantly influences both the distant failure (P = 0.006) and disease progression (P = 0.001). In N1 disease, the occurrence of unilateral and bilateral RPN metastasis resulted in significantly different outcomes of the disease-specific survival (P = 0.045) and progression-free survival (P = 0.049). The co-occurrence of bilateral RPN and cervical lymph nodes (CLN) metastasis was an independent adverse prognostic factor (P
- Subjects :
- Oncology
medicine.medical_specialty
medicine.medical_treatment
Disease
Metastasis
Internal medicine
medicine
Humans
Neoplasm Staging
Retrospective Studies
Nasopharyngeal Carcinoma
business.industry
Incidence (epidemiology)
Carcinoma
Hazard ratio
Nasopharyngeal Neoplasms
Retrospective cohort study
General Medicine
Prognosis
medicine.disease
Magnetic Resonance Imaging
Radiation therapy
medicine.anatomical_structure
Nasopharyngeal carcinoma
Cervical lymph nodes
Disease Progression
Lymph Nodes
Radiotherapy, Intensity-Modulated
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 17437563 and 17437555
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Asia-Pacific Journal of Clinical Oncology
- Accession number :
- edsair.doi.dedup.....e642eed0ef35b1670b0b386659699920