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Echocardiographic evaluation of the right ventricular dimension and systolic function in dogs with pulmonary hypertension
- Source :
- Journal of Veterinary Internal Medicine
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- BACKGROUND Right ventricular (RV) enlargement and dysfunction are associated with prognosis in humans with pulmonary hypertension (PH). HYPOTHESIS/OBJECTIVES To assess RV size and systolic function in dogs with PH and to determine if they are associated with disease severity and right-sided congestive heart failure (R-CHF). ANIMALS 89 dogs with PH and 74 healthy dogs. METHODS Prospective observational study. PH was classified according to the tricuspid regurgitation pressure gradient. RV end-diastolic area (RVEDA) index was calculated as RVEDA divided by body surface area. RV systolic function was assessed with the tricuspid annular plane systolic excursion (TAPSE) and the RV fractional area change (FAC) normalized for body weight (TAPSEn and FACn, respectively). RESULTS RVEDA index was higher in dogs with moderate PH (10.8 cm2 /m2 ; range, 6.2-14.4 cm2 /m2 ) and severe PH (12.4 cm2 /m2 ; range, 7.7-21.4 cm2 /m2 ) than in those with mild PH (8.4 cm2 /m2 ; range, 4.8-11.6 cm2 /m2 ) and control dogs (8.5 cm2 /m2 ; range, 2.8-11.6 cm2 /m2 ; P < .001). RVEDA index was significantly higher in dogs with R-CHF (13.7 cm2 /m2 ; range, 11.0-21.4 cm2 /m2 ) than in dogs without R-CHF (9.4 cm2 /m2 ; range, 4.8-17.1 cm2 /m2 ; P < .001). The severity of tricuspid regurgitation (TR) was the only independent predictor of the RVEDA index (P < .001). TAPSEn and FACn were not significantly different among varying degrees of PH severity and between dogs with and without R-CHF. CONCLUSIONS AND CLINICAL IMPORTANCE The RVEDA index can be used to evaluate RV size in dogs. It can provide additional information in dogs with PH and predict R-CHF. Severity of TR is the main determinant of RV enlargement in dogs with PH.
- Subjects :
- Male
10253 Department of Small Animals
3400 General Veterinary
Standard Article
Systolic function
030204 cardiovascular system & hematology
0403 veterinary science
0302 clinical medicine
right ventricular size
Dog Diseases
Prospective Studies
Prospective cohort study
tricuspid regurgitation
right ventricular enlargement
Observer Variation
Body surface area
630 Agriculture
Pulmonary
04 agricultural and veterinary sciences
Standard Articles
congestive heart failure
Echocardiography
Hypertension
Cardiology
Veterinary (all)
Female
medicine.medical_specialty
Animals
Dogs
Heart Ventricles
Hypertension, Pulmonary
Reproducibility of Results
040301 veterinary sciences
Regurgitation (circulation)
Body weight
03 medical and health sciences
Disease severity
Internal medicine
medicine
General Veterinary
business.industry
medicine.disease
Pulmonary hypertension
Heart failure
570 Life sciences
biology
SMALL ANIMAL
business
Subjects
Details
- ISSN :
- 08916640
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Internal Medicine
- Accession number :
- edsair.doi.dedup.....e64b6382c34fbe178ea116307a94b0e3