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Low anthracyclines doses-induced cardiotoxicity in acute lymphoblastic leukemia long-term female survivors
- Source :
- Pediatric bloodcancer. 55(7)
- Publication Year :
- 2010
-
Abstract
- Background High dosage anthracyclines in pediatric patients with acute lymphoblastic leukemia (ALL) is associated with cardiotoxicity. However, data on the cardiac effects of lower cumulative doses of these drugs are not conclusive. The aim of this study was to assess the cardiac effects of low cumulative anthracycline doses in long-term survivors of ALL. Procedure Echocardiograms were performed on 62 long-term ALL survivors, without any overt or sub-clinical signs or symptoms of heart failure. The interval after stopping therapy was 12.6 ± 4.3 years; the mean cumulative dose of anthracyclines was 228.2 ± 42.3 mg/m2. Left ventricular (LV) structure and function were studied by echocolor-Doppler. An age, gender and body surface area (BSA) matched group of healthy subjects was used as controls. Cardiac data were analyzed before and after BSA normalization. Results Long term survivors of ALL, showed a lower LV mass index, interventricular septal and posterior wall thickness, which were independently related to gender and to age at which the ALL diagnosis was made. Data analyzed according to gender showed that abnormalities were confined to the female group. No alterations were observed in the ALL male group versus the corresponding control group. No relationship was observed between the echocardiografic abnormalities and the duration of follow-up or the anthracycline mean dose employed. Conclusions In the absence of any signs or symptoms of heart failure, female ALL survivors treated with low cumulative anthracycline doses, showed a reduced LV mass and wall thickness. This suggests that in female ALL survivors an echocardyographic follow-up should be recommended. Pediatr Blood Cancer. 2010;55:1343–1347. © 2010 Wiley-Liss, Inc.
- Subjects :
- Adult
Male
medicine.medical_specialty
Anthracycline
Adolescent
Lymphoblastic Leukemia
Heart failure
Acute lymphoblastic leukemia
Young Adult
Risk Factors
Internal medicine
medicine
Humans
Mass index
Anthracyclines
Survivors
Child
Body surface area
Cardiotoxicity
Antibiotics, Antineoplastic
Cumulative dose
business.industry
Heart
Hematology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Surgery
Leukemia
Oncology
Echocardiography
Pediatrics, Perinatology and Child Health
Cardiology
Female
business
Cardiomyopathies
Subjects
Details
- ISSN :
- 15455017
- Volume :
- 55
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Pediatric bloodcancer
- Accession number :
- edsair.doi.dedup.....e64ddfa45796b1719a475c97cd4b1053