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Progressive microstructural alterations in subcortical nuclei in Parkinson's disease: A diffusion magnetic resonance imaging study
- Source :
- Parkinsonism & Related Disorders. 88:82-89
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- To explore the microstructural alterations in subcortical nuclei in Parkinson's disease (PD) at different stages with diffusion kurtosis imaging (DKI) and tensor imaging and to test the performance of diffusion metrics in identifying PD.108 PD patients (64 patients in early-stage PD group (EPD) and 44 patients in moderate-late-stage PD group (MLPD)) and 64 healthy controls (HC) were included. Tensor and kurtosis metrics in the subcortical nuclei were compared. Partial correlation was used to correlate the diffusion metrics and Unified Parkinson's Disease Rating Scale part-III (UPDRS-III) score. Logistic regression and receiver operating characteristic analysis were applied to test the diagnostic performance of the diffusion metrics.Compared with HC, both EPD and MLPD patients showed higher fractional anisotropy and axial diffusivity, lower mean kurtosis (MK) and axial kurtosis in substantia nigra, lower MK and radial kurtosis (RK) in globus pallidus (GP) and thalamus (all p 0.05). Compared with EPD, MLPD patients showed lower MK and RK in GP and thalamus (all p 0.05). MK and RK in GP and thalamus were negatively correlated with UPDRS-III score (all p 0.01). The logistic regression model combining kurtosis and tensor metrics showed the best performance in diagnosing PD, EPD, and MLPD (areas under curve were 0.817, 0.769, and 0.914, respectively).PD has progressive microstructural alterations in the subcortical nuclei. DKI is sensitive to detect microstructural alterations in GP and thalamus during PD progression. Combining kurtosis and tensor metrics can achieve a good performance in diagnosing PD.
- Subjects :
- Male
0301 basic medicine
Parkinson's disease
Thalamus
Substantia nigra
Globus Pallidus
03 medical and health sciences
0302 clinical medicine
Nuclear magnetic resonance
Fractional anisotropy
medicine
Humans
Diffusion Kurtosis Imaging
Aged
medicine.diagnostic_test
business.industry
Parkinson Disease
Magnetic resonance imaging
Middle Aged
medicine.disease
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
030104 developmental biology
Globus pallidus
nervous system
Neurology
Disease Progression
Kurtosis
Female
Neurology (clinical)
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 13538020
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- Parkinsonism & Related Disorders
- Accession number :
- edsair.doi.dedup.....e654bdbfcbea774f0ced1c7a6afbb6d0