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Voltage-Driven Flipping of Zwitterionic Artificial Channels in Lipid Bilayers to Rectify Ion Transport
- Source :
- Journal of the American Chemical Society. 143:11332-11336
- Publication Year :
- 2021
- Publisher :
- American Chemical Society (ACS), 2021.
-
Abstract
- We developed a voltage-sensitive artificial transmembrane channel by mimicking the dipolar structure of natural alamethicin channel. The artificial channel featured a zwitterionic structure and could undergo voltage-driven flipping in the lipid bilayers. Importantly, this flipping of the channel could lead to their directional alignment in the bilayers and rectifying behavior for ion transport.
- Subjects :
- Physics::Biological Physics
Ion Transport
Silver
Alamethicin
Molecular Structure
Chemistry
Lipid Bilayers
Electric Conductivity
Silver Compounds
General Chemistry
Condensed Matter::Mesoscopic Systems and Quantum Hall Effect
Biochemistry
Ion Channels
Catalysis
Quantitative Biology::Subcellular Processes
chemistry.chemical_compound
Colloid and Surface Chemistry
Chemical physics
Lipid bilayer
Ion transporter
Computer Science::Information Theory
Voltage
Communication channel
Subjects
Details
- ISSN :
- 15205126 and 00027863
- Volume :
- 143
- Database :
- OpenAIRE
- Journal :
- Journal of the American Chemical Society
- Accession number :
- edsair.doi.dedup.....e681a26b534b4267dc604072bf111709