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SUPPRESSION OF IDIOTYPIC SPECIFICITIES IN ADULT MICE BY ADMINISTRATION OF ANTIIDIOTYPIC ANTIBODY
- Source :
- The Journal of Experimental Medicine
- Publication Year :
- 1972
- Publisher :
- Rockefeller University Press, 1972.
-
Abstract
- It has previously been shown that there are extensive idiotypic cross-reactions among antiphenylarsonate antibodies of A/J mice. The present work indicates that administration, into normal, adult A/J mice, of rabbit antiidiotypic antibody directed to A/J antiphenylarsonate antibody suppresses almost completely the subsequent production of antibody of the corresponding idiotype. No effect was noted on the formation of antibodies to the protein carrier or of antiphenylarsonate antibody of a different idiotype. The data are consistent with central suppression of production of the idiotypic antibody mediated through interaction with immunoglobulin receptors on lymphocytes.
- Subjects :
- Idiotype
Immunodiffusion
medicine.medical_treatment
Immunology
Mice, Inbred Strains
Cross Reactions
Arsenicals
Article
Immunoglobulin G
Isoantibodies
Mice
Antibody Specificity
Iodine Isotopes
medicine
Animals
Immunology and Allergy
Receptor
Immunosuppression Therapy
biology
Hemocyanin
Molecular biology
Transplantation
Hemocyanins
biology.protein
Rabbits
Antibody
Azo Compounds
Subjects
Details
- ISSN :
- 15409538 and 00221007
- Volume :
- 135
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental Medicine
- Accession number :
- edsair.doi.dedup.....e68588b8ecf636cdee6301ec10d684f8
- Full Text :
- https://doi.org/10.1084/jem.135.6.1293