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Group II metabotropic glutamate receptors in the striatum of non-human primates: Dysregulation following chronic cocaine self-administration

Authors :
Michael A. Nader
Thomas J.R. Beveridge
Linda J. Porrino
Hilary R. Smith
Source :
Neuroscience Letters. 496:15-19
Publication Year :
2011
Publisher :
Elsevier BV, 2011.

Abstract

A growing body of evidence has demonstrated a role for group II metabotropic glutamate receptors (mGluRs) in the reinforcing effects of cocaine. These receptors are important given their location in limbic-related areas, and their ability to control the release of glutamate and other neurotransmitters. They are also potential targets for novel pharmacotherapies for cocaine addiction. The present study investigated the impact of chronic cocaine self-administration (9.0mg/kg/session for 100 sessions, 900 mg/kg total intake) on the densities of group II mGluRs, as assessed with in vitro receptor autoradiography, in the striatum of adult male rhesus monkeys. Binding of [(3)H]LY341495 to group II mGluRs in control animals was heterogeneous, with a medial to lateral gradient in binding density. Significant elevations in the density of group II mGluRs following chronic cocaine self-administration were measured in the dorsal, central and ventral portions of the caudate nucleus (P

Details

ISSN :
03043940
Volume :
496
Database :
OpenAIRE
Journal :
Neuroscience Letters
Accession number :
edsair.doi.dedup.....e690a83dc2f026cb34d20b139c002b99
Full Text :
https://doi.org/10.1016/j.neulet.2011.03.077