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Characteristics of Esophageal Cancer Cases in Tanzania
- Source :
- Journal of Global Oncology, Journal of Global Oncology, Vol 4, Pp 1-10 (2017), Journal of global oncology, vol 4, iss 4
- Publication Year :
- 2018
- Publisher :
- American Society of Clinical Oncology (ASCO), 2018.
-
Abstract
- Purpose Age-standardized incidence rates for esophageal cancer (EC) in East Africa have been reported as disproportionately high compared with the worldwide incidence of nine per 100,000 population. This study aimed to characterize EC cases seen at Muhimbili National Hospital and Ocean Road Cancer Institute in Dar es Salaam, Tanzania. Methods Demographic, clinical, and treatment variables were abstracted from charts of patients who received care for a diagnosis of EC at one or both institutions between 2011 and 2013. Categorical data were summarized as frequency counts and percentages. Continuous data were presented as medians and ranges. To compare men and women, Pearson’s χ2 and two-sample t tests were applied. Results Seven hundred thirty-eight unique cases of EC were identified, of whom 68% were men and the median age was 60 years (range, 19 to 95 years). Notably, 93 cases (13%) were ≤ 40 years old at diagnosis. Squamous cell carcinoma was the dominant histology, comprising 90% of cases with documented histopathology. However, 34% of cases with a diagnosis of EC were not pathologically confirmed. The stage was documented as locoregional in 4% of cases, locally advanced in 20% of cases, metastatic in 14% of cases, and unknown in 63% of cases. Of 430 patients who received treatment at Ocean Road Cancer Institute, 76% were treated with radiation, 44% were treated with chemotherapy, 3% underwent a cancer-related surgical procedure, and 10% of cases received no cancer-directed therapy. The median overall survival for all patients was 6.9 months (95% CI, 5.0 to 12.8), regardless of stage at presentation. Conclusion Between 2011 and 2013, cases of EC represented a large clinical burden at both institutions.
- Subjects :
- Male
Cancer Research
Esophageal Neoplasms
Epidemiology
Tanzania
0302 clinical medicine
Gastrointestinal Cancer
80 and over
Medicine
Cancer
Aged, 80 and over
education.field_of_study
biology
Incidence (epidemiology)
ORIGINAL REPORTS
Middle Aged
Esophageal cancer
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Diagnosis & Staging
Oncology
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Female
030211 gastroenterology & hepatology
Adult
medicine.medical_specialty
Population
and over
lcsh:RC254-282
Young Adult
03 medical and health sciences
Rare Diseases
Dar es salaam
Clinical Research
Internal medicine
East africa
Humans
Basal cell
education
Aged
Retrospective Studies
business.industry
Prevention
Carcinoma
medicine.disease
biology.organism_classification
Survival Analysis
Surgery
Squamous Cell
business
Subjects
Details
- ISSN :
- 23789506
- Database :
- OpenAIRE
- Journal :
- Journal of Global Oncology
- Accession number :
- edsair.doi.dedup.....e6a8bfac0eececd7a48c25650e9f6482