Back to Search
Start Over
Human papillomavirus in semen and the risk for male infertility: a systematic review and meta-analysis
- Source :
- BMC Infectious Diseases, BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-9 (2017)
- Publication Year :
- 2017
- Publisher :
- BioMed Central, 2017.
-
Abstract
- Background Human papillomavirus (HPV) is one of the most prevalent sexually transmitted viruses. Despite the increasing evidence of HPV prevalence in semen, the worldwide distribution of HPV types in semen and risk for male infertility remain inconclusive. Methods Four electronic databases were searched for English language studies conducted between January 1990 and December 2016 that reported HPV DNA prevalence in semen. Based on the PRISMA guidelines, HPV prevalence was estimated among general population and fertility clinic attendees, respectively, and heterogeneity testing was performed using Cochran’s Q and I 2 statistics. The association between HPV positivity and male infertility was evaluated by a meta-analysis of case-control studies. Results A total of 31 eligible studies comprising 5194 males were included. The overall prevalence of HPV DNA in semen was 11.4% (95% CI = 7.8-15.0%) in general population (n = 2122) and 20.4% (95% CI = 16.2-24.6%) in fertility clinic attendees (n = 3072). High-risk type prevalence was 10.0% (95% CI = 5.9-14.0%) and 15.5% (95% CI = 11.4-19.7%), respectively. HPV16 was the most common type, with a prevalence of 4.8% (95% CI = 1.7-7.8%) in general population and 6.0% (95% CI = 3.8-8.2%) in fertility clinic attendees. A significantly increased risk of infertility was found for males with HPV positivity in semen (OR = 2.93, 95% CI = 2.03-4.24). Conclusions Seminal HPV infection is common worldwide, which may contribute to the risk of male infertility. Electronic supplementary material The online version of this article (10.1186/s12879-017-2812-z) contains supplementary material, which is available to authorized users.
- Subjects :
- 0301 basic medicine
Infertility
Male
Risk
medicine.medical_specialty
Human papillomavirus
Databases, Factual
Population
Semen
lcsh:Infectious and parasitic diseases
Male infertility
03 medical and health sciences
0302 clinical medicine
Medical microbiology
medicine
Prevalence
Odds Ratio
Humans
lcsh:RC109-216
education
Papillomaviridae
Infertility, Male
Gynecology
education.field_of_study
030219 obstetrics & reproductive medicine
business.industry
Obstetrics
Papillomavirus Infections
HPV infection
medicine.disease
Meta-analysis
030104 developmental biology
Infectious Diseases
Tropical medicine
DNA, Viral
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712334
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- BMC Infectious Diseases
- Accession number :
- edsair.doi.dedup.....e6b111fcf2b66408e5349374af605c25