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Fate of intravenously administered gold nanoparticles in hair follicles: follicular delivery, pharmacokinetic interpretation, and excretion
- Publication Year :
- 2012
- Publisher :
- Germany : Wiley-VCH Verlag GmbH, 2012.
-
Abstract
- Gold nanoparticles (GNPs) are intravenously administered to mice. Deposition at the pilosebacious unit and whiskers is visualized with X-ray fl uorescence after 30 minutes and 14 days. After 30 minutes the dermal papilla, bulge region, and root sheath all contain NPs. GNPs are driven externally out from follicles, counteractive to transfollicular delivery. After 14 days, gold bands in hairs refl ect pharmacokinetic profi les indicating blood concentration kinetics. Elimination rate constants infer half-lives from 3 hairs from an individual mouse within reasonable agreement (6.08, 7.15, and 8.66 hours). 3D reconstruction of NP distributions with confocal microscopy identifi es aggregates within the medullary canal. Intermittent NP deposition continues randomly over the two week period demonstrating prolonged NP mobility in vivo. NPs are still retained at the hair bulb after 14 days. The observations further account for the excretory mechanisms of NPs and their behavior in the pilosebacous unit, and demonstrate monitoring pharmacokinetic behavior in individual animals. Refereed/Peer-reviewed
- Subjects :
- Male
Materials science
Metabolic Clearance Rate
Biomedical Engineering
Pharmaceutical Science
Metal Nanoparticles
Root sheath
law.invention
Biomaterials
Excretion
Diffusion
Mice
Pharmacokinetics
Confocal microscopy
law
In vivo
medicine
Animals
Tissue Distribution
Mice, Inbred BALB C
integumentary system
Anatomy
Dermal papillae
medicine.anatomical_structure
Colloidal gold
Excretory system
Biophysics
Administration, Intravenous
Gold
Hair Follicle
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....e6c626d4c0697bb2ad606edc67141ef9