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Glutathione-S-transferase T1 and M1 gene polymorphisms in Greek patients with multiple sclerosis: a pilot study
- Source :
- European journal of neurology. 14(5)
- Publication Year :
- 2007
-
Abstract
- Oxidative stress has been implicated in the pathogenesis of multiple sclerosis (MS). Glutathione-S-transferases (GSTs) are detoxification enzymes, evolved to protect cells against reactive oxygen metabolites. Both GSTT1 and GSTM1 genes exhibit a homozygous deletion polymorphism (null genotype) leading to abolished enzyme activity. We studied the impact of the GSTT1 and GSTM1 polymorphisms on MS susceptibility in a case–control study of 47 Greek patients and 165 controls. Correlations between genotype, gender and disability status were also investigated. The incidence of both GSTT1 and GSTM1 genotypes did not differ significantly between controls and patients. A significantly increased frequency of GSTM1 null genotype was found amongst female patients (65.5%) as compared with males (33.3%, P ¼ 0.04). The results suggest that GSTT1 and GSTM1 have no major pathogenetic role on the MS occurrence, nor any strong modifying effect on the disability status. The higher incidence of GSTM1 null genotype observed in female patients, suggests a possible role of the GSTM1 detoxification pathway in a gender-dependent manner.
- Subjects :
- Adult
Central Nervous System
Genetic Markers
Male
medicine.medical_specialty
Multiple Sclerosis
Genotype
DNA Mutational Analysis
Pilot Projects
Glutathione-S-Transferase T1
medicine.disease_cause
Pathogenesis
Internal medicine
Female patient
Medicine
Humans
Genetic Testing
Sex Distribution
neoplasms
Gene
Aged
Glutathione Transferase
Genetics
Aged, 80 and over
Sex Characteristics
Polymorphism, Genetic
integumentary system
biology
Greece
business.industry
Multiple sclerosis
Free Radical Scavengers
Middle Aged
medicine.disease
Glutathione
Enzyme assay
Oxidative Stress
Endocrinology
Neurology
biology.protein
Female
Neurology (clinical)
business
Oxidative stress
Subjects
Details
- ISSN :
- 14681331
- Volume :
- 14
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- European journal of neurology
- Accession number :
- edsair.doi.dedup.....e6ca36ecb1e9f6622167cfab5bd16bc6