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The -374T/A variant of the rage gene promoter is associated with clinical restenosis after coronary stent placement
- Source :
- Scopus-Elsevier
- Publication Year :
- 2008
-
Abstract
- Upregulation of the receptor for advanced glycation end products (RAGE) may play a crucial role in neointimal formation upon vessel injury. The −374T/A variant of the RAGE gene promoter, which has been associated with an altered expression of the cell-surface receptor, could exert a protective effect toward the development of vascular disease. The aim of this study is to determine the impact of this common genetic variant in the occurrence of clinical in-stent restenosis after coronary stent implantation. The −374T/A polymorphism of the RAGE gene promoter was evaluated by PCR-RFLPs in 267 patients with coronary artery disease who underwent coronary stent implantation and a subsequent coronary angiography 6–9 months later for suspected restenosis. In-stent restenosis was assessed by means of quantitative angiography. Carriers of the-374AA genotype showed a significantly reduced risk of developing restenosis after percutaneous transluminal intervention than non-carriers. To determine whether the protective effect of the homozygous AA genotype toward clinical restenosis was independent of potential confounders, we performed multivariable logistic regression analysis. After allowance for clinical and biochemical risk factors and stent length, the AA genotype remained significantly associated with a reduced prevalence of in-stent restenosis. No relation was evident between the RAGE genotype and established cardiovascular risk factors. In conclusion, the −374AA genotype of the RAGE gene promoter could be associated with a reduced risk of in-stent restenosis after coronary stent implantation.
- Subjects :
- Genetic Markers
Male
medicine.medical_specialty
Genotype
medicine.medical_treatment
Immunology
Receptor for Advanced Glycation End Products
Risk Assessment
RAGE (receptor)
Body Mass Index
Coronary artery disease
Cohort Studies
Coronary Restenosis
03 medical and health sciences
0302 clinical medicine
Restenosis
Risk Factors
Internal medicine
Diabetes mellitus
Coronary stent
Immunology and Allergy
Medicine
Humans
cardiovascular diseases
Angioplasty, Balloon, Coronary
Receptors, Immunologic
Promoter Regions, Genetic
Aged
Pharmacology
Sex Characteristics
Polymorphism, Genetic
business.industry
Vascular disease
Reverse Transcriptase Polymerase Chain Reaction
Stent
DNA
Middle Aged
medicine.disease
Cardiovascular Diseases
030220 oncology & carcinogenesis
Data Interpretation, Statistical
Cardiology
Female
Stents
business
030215 immunology
Subjects
Details
- ISSN :
- 03946320
- Volume :
- 20
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- International journal of immunopathology and pharmacology
- Accession number :
- edsair.doi.dedup.....e6db2eba4dc20ee5cf7a476f2d9009f1