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P53 immunohistochemical expression does not correlate with clinical features in 207 carcinomas of the oral cavity and in the head and neck region
- Source :
- Clinical oral investigations. 18(1)
- Publication Year :
- 2012
-
Abstract
- The present study aims to investigate the relevance of immunohistochemical p53 expression in carcinomas of the oral cavity and of the head and neck region. Long-term clinical and histopathological follow-up findings as well as HPV status are correlated with the results of this examination.Sections made from two tissue arrays composed of 222 oral squamous cell carcinomas and 427 squamous cell carcinomas of the head and neck region, respectively, were examined for p53 expression and Ki-67 index by means of immunohistochemistry. Correlation of long-term clinical findings of the patients and pathological features of tumours with laboratory results were examined statistically.No significant correlation was found between the p53 immunohistochemical expression in the 207 oral carcinomas and features of the tumours and patient outcomes. There was no significant association between the Ki-67 labelling index and the p53 expression.Our failure in detecting any association of the p53 immunohistochemical expression regardless of HPV status with clinical features of these tumours suggests it lacks a prognostic value for squamous cell carcinomas of the oral cavity.The prognostic value of p53 immunostaining in oral squamous carcinoma is not clarified yet. In the present study, there is no impact on any prognostical item nor even a correlation with cell proliferation (Ki-67) regardless of HPV status.
- Subjects :
- Oncology
Male
medicine.medical_specialty
Alphapapillomavirus
Oral cavity
Polymerase Chain Reaction
Text mining
Internal medicine
medicine
Humans
Head and neck
General Dentistry
P53 expression
Hpv status
DNA Primers
Base Sequence
business.industry
Prognosis
Immunohistochemistry
Expression (architecture)
Head and Neck Neoplasms
Carcinoma, Squamous Cell
Female
Mouth Neoplasms
Tumor Suppressor Protein p53
business
Subjects
Details
- ISSN :
- 14363771
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical oral investigations
- Accession number :
- edsair.doi.dedup.....e6fd80e477550f12dd83692c19ad5938