P-41 TRENDS IN HOSPITALIZATION, CHARACTERISTICS AND MORTALITY OF HOSPITALIZED PATIENTS WITH CIRRHOSIS IN CHILE

Introduction Cirrhosis is a frequent cause of hospitalization and is the 3rd cause of death in adults in Chile. Objective To describe the trend in hospitalizations and mortality of hospitalized patients with cirrhosis in Chile. Methods Descriptive analysis of combination of cross-sections, regression models (STATA 15). Population data from the MINSAL-DEIS 2001-2018 hospital discharge databases (HD) were used. HD were identified by C by codes K70.3, K743, K745, K746 (ICD-10). Results Between 2001-2018 there were 28,181 HD by cirrhosis. Mean age 60 years; 63% men. 19,174 (68%) were for cirrhosis not associated with alcohol (CNAA) and 9,008 (32%) for alcohol (CAA). 4,903 (17.4%) of the HD were as deceased; these decreased from 521 (20.7%) in 2001 to 178 (12.5%) in 2018. Mortality was higher in CAA (21.4% vs 15.5%). 3 periods with different trends in the rate of HD per C (x100,000) are identified: 2001-2007 decreased by 53%, from 16.2 (2,518 HD) to 8.5 (1,411); 2007-2013 decreased 28% reaching 6.1 (1,067 HD); 2013-2018 increased 24.6%, reaching 7.6% (1,424 HD). The decrease in the second period and the increase in the third period were 3 times greater in CNAA than in CAA. By sex and type of cirrhosis, the third-period increase in CAA / women began in 2017. Conclusion There is an increase in HD due to cirrhosis from 2013, relevant and worrying information. Its cause should be investigated in future studies. The decrease in deceased HD may be due to better knowledge and management of the disease.