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Effectiveness of topical application of ostrich oil on the healing of Staphylococcus aureus- and Pseudomonas aeruginosa-infected wounds
Effectiveness of topical application of ostrich oil on the healing of Staphylococcus aureus- and Pseudomonas aeruginosa-infected wounds
- Source :
- Connective tissue research. 59(3)
- Publication Year :
- 2017
-
Abstract
- Management of infected wounds is one of the major challenges that surgeons and nurses face. Several antimicrobial agents have been used, but the toxicity, drug resistance, and their effect on the healing process remain a matter of concern. The present study was designed to analyze the accelerative impact of topical application of ostrich oil on infected wounds in a mouse model.72 BALB/c mice were divided into four main groups of control-sham, mupirocin, and two treatment groups receiving 2% and 4% (w/w) concentrations of ostrich oil, topically. The mice were routinely anesthetized and wounds were created by excising the skin with a 5-mm biopsy punch. Immediately after wounding, an aliquot of 25 × 10The wound area significantly decreased (p 0.05) in the treated animals. There was a significant increase (p 0.05) in new vessels, fibroblasts count, and collagen deposition in the ostrich oil-treated animals. Expression of VEGF, TGF-β1, and FGF-2 revealed the immunomodulation and angiogenesis effects of the ostrich oil on wound healing.Our study demonstrated that ostrich oil may be a useful treatment in infected cutaneous wounds.
- Subjects :
- 0301 basic medicine
Male
Vascular Endothelial Growth Factor A
Staphylococcus aureus
Drug resistance
medicine.disease_cause
Biochemistry
Microbiology
03 medical and health sciences
0302 clinical medicine
Rheumatology
medicine
Animals
Orthopedics and Sports Medicine
Molecular Biology
Skin
Mice, Inbred BALB C
Wound Healing
business.industry
Pseudomonas aeruginosa
Plant Extracts
Cell Biology
Fibroblasts
Antimicrobial
Infected wound
030104 developmental biology
030220 oncology & carcinogenesis
Toxicity
Collagen
business
Subjects
Details
- ISSN :
- 16078438
- Volume :
- 59
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Connective tissue research
- Accession number :
- edsair.doi.dedup.....e7245ad5816c829466db39ab1a7958a3