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Effectiveness of topical application of ostrich oil on the healing of Staphylococcus aureus- and Pseudomonas aeruginosa-infected wounds

Effectiveness of topical application of ostrich oil on the healing of Staphylococcus aureus- and Pseudomonas aeruginosa-infected wounds

Authors :
Ahmad Oryan
Mahsa Vahid
Mohammad Reza Farahpour
Source :
Connective tissue research. 59(3)
Publication Year :
2017

Abstract

Management of infected wounds is one of the major challenges that surgeons and nurses face. Several antimicrobial agents have been used, but the toxicity, drug resistance, and their effect on the healing process remain a matter of concern. The present study was designed to analyze the accelerative impact of topical application of ostrich oil on infected wounds in a mouse model.72 BALB/c mice were divided into four main groups of control-sham, mupirocin, and two treatment groups receiving 2% and 4% (w/w) concentrations of ostrich oil, topically. The mice were routinely anesthetized and wounds were created by excising the skin with a 5-mm biopsy punch. Immediately after wounding, an aliquot of 25 × 10The wound area significantly decreased (p 0.05) in the treated animals. There was a significant increase (p 0.05) in new vessels, fibroblasts count, and collagen deposition in the ostrich oil-treated animals. Expression of VEGF, TGF-β1, and FGF-2 revealed the immunomodulation and angiogenesis effects of the ostrich oil on wound healing.Our study demonstrated that ostrich oil may be a useful treatment in infected cutaneous wounds.

Details

ISSN :
16078438
Volume :
59
Issue :
3
Database :
OpenAIRE
Journal :
Connective tissue research
Accession number :
edsair.doi.dedup.....e7245ad5816c829466db39ab1a7958a3