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Antidotes for childhood toxidromes
- Source :
- Drugs in Context, Drugs in Context, Vol 10, Pp 1-10 (2021)
- Publication Year :
- 2021
- Publisher :
- BioExcel, 2021.
-
Abstract
- Background: Poisoning causes significant morbidity and sometimes mortality in children worldwide. The clinical skill of toxidrome recognition followed by the timely administration of an antidote specific for the poison is essential for the management of children with suspected poisoning. This is a narrative review on antidotes for toxidromes in paediatric practice. Methods: A literature search was conducted on PubMed with the keywords “antidote”, “poisoning”, “intoxication”, “children” and “pediatric”. The search was customized by applying the appropriate filters (species: humans; age: birth to 18 years) to obtain the most relevant articles for this review article. Results: Toxidrome recognition may offer a rapid guide to possible toxicology diagnosis such that the specific antidote can be administered in a timely manner. This article summarizes toxidromes and their respective antidotes in paediatric poisoning, with an emphasis on the symptomatology and source of exposure. The antidote and specific management for each toxidrome are discussed. Antidotes are only available for a limited number of poisons responsible for intoxication. Antidotes for common poisonings include N-acetyl cysteine for paracetamol and sodium thiosulphate for poisoning by cyanide. Conclusion: Poisoning is a common cause of paediatric injury. Physicians should be familiar with the recognition of common toxidromes and promptly use specific antidotes for the management of childhood toxidromes.
- Subjects :
- medicine.medical_specialty
toxidrome
medicine.medical_treatment
RM1-950
Review
03 medical and health sciences
0302 clinical medicine
intoxication
Paediatric injury
medicine
030212 general & internal medicine
Antidote
Intensive care medicine
Toxidrome
Pharmacology
business.industry
030208 emergency & critical care medicine
General Medicine
medicine.disease
Review article
paediatric poisoning
Molecular Medicine
Narrative review
Therapeutics. Pharmacology
extracorporeal treatment
business
antidote
Clinical skills
Subjects
Details
- ISSN :
- 17404398
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Drugs in Context
- Accession number :
- edsair.doi.dedup.....e724b49dcd050042791d6d1f643f3730