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Contemporary kidney transplantation has a limited impact on bone microarchitecture
- Source :
- Bone Reports, 16:101172. Elsevier Inc., Meng, C, Jørgensen, H M S, Verlinden, L, Bravenboer, N, de Loor, H, D'Haese, P C, Carmeliet, G & Evenepoel, P 2022, ' Contemporary kidney transplantation has a limited impact on bone microarchitecture ', Bone Reports, vol. 16, 101172 . https://doi.org/10.1016/j.bonr.2022.101172, Meng, C, Jørgensen, H S, Verlinden, L, Bravenboer, N, de Loor, H, D'Haese, P C, Carmeliet, G & Evenepoel, P 2022, ' Contemporary kidney transplantation has a limited impact on bone microarchitecture ', Bone Reports, vol. 16, 101172 . https://doi.org/10.1016/j.bonr.2022.101172, Bone Reports, Bone Reports, Vol 16, Iss, Pp 101172-(2022)
- Publication Year :
- 2022
-
Abstract
- Bone microarchitecture is an important component of bone quality and disturbances may reduce bone strength and resistance to trauma. Kidney transplant recipients have an excess risk of fractures, and bone loss affecting both trabecular and cortical bone compartments have been demonstrated after kidney transplantation. The primary aim of this study was to investigate the impact of kidney transplantation on trabecular and cortical bone microarchitecture, assessed by histomorphometry and micro computed tomography (μCT). Iliac crest bone biopsies, analyzed by bone histomorphometry and μCT, were performed at time of kidney transplantation and 12 months post-transplantation in an unselected cohort of 30 patients. Biochemical markers of mineral metabolism and bone turnover were measured at both time-points. At 12 months post-transplantation, bone turnover was low in 5 (17%) and normal in 25 (83%) patients. By histomorphometry, bone remodeling normalized, with decreases in eroded perimeters (4.0 to 2.1%, p = 0.02) and number of patients with marrow fibrosis (41 to 0%, p
- Subjects :
- TRAP5b, tartrate resistant acid phosphatase type 5b
μCT, micro computed tomography
HRpQCT, high-resolution peripheral quantitative computed tomography
Endocrinology, Diabetes and Metabolism
3D, three-dimensional
BMD, bone mineral density
CKD, chronic kidney disease
eGFR, estimated glomerular filtration rate
Diseases of the musculoskeletal system
X-Ray Microtomography
PINP, intact pro-collagen type I N-terminal pro-peptide
TMV, Turnover, mineralization, and volume
DXA, dual-energy x-ray absorptiometry
BALP, bone-specific alkaline phosphatase
Kidney transplantation
Chronic kidney disease – mineral and bone disorder
RC925-935
2D, two-dimensional
Osteoporosis
Orthopedics and Sports Medicine
Human medicine
PTH, parathyroid hormone
Bone density
Bone histomorphometry
Subjects
Details
- Language :
- English
- ISSN :
- 23521872
- Database :
- OpenAIRE
- Journal :
- Bone Reports, 16:101172. Elsevier Inc., Meng, C, Jørgensen, H M S, Verlinden, L, Bravenboer, N, de Loor, H, D'Haese, P C, Carmeliet, G & Evenepoel, P 2022, ' Contemporary kidney transplantation has a limited impact on bone microarchitecture ', Bone Reports, vol. 16, 101172 . https://doi.org/10.1016/j.bonr.2022.101172, Meng, C, Jørgensen, H S, Verlinden, L, Bravenboer, N, de Loor, H, D'Haese, P C, Carmeliet, G & Evenepoel, P 2022, ' Contemporary kidney transplantation has a limited impact on bone microarchitecture ', Bone Reports, vol. 16, 101172 . https://doi.org/10.1016/j.bonr.2022.101172, Bone Reports, Bone Reports, Vol 16, Iss, Pp 101172-(2022)
- Accession number :
- edsair.doi.dedup.....e72d399ecd19c505e6f9315b1405df7f
- Full Text :
- https://doi.org/10.1016/j.bonr.2022.101172