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Tetramethylpyrazine attenuates blood-brain barrier disruption in ischemia/reperfusion injury through the JAK/STAT signaling pathway
- Source :
- European Journal of Pharmacology. 854:289-297
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Tetramethylpyrazine (TMP) has been studied in depth and is widely used in the treatment of many kinds of diseases in China. However, whether it has neuroprotective effects on cerebral ischemia remains unclear. An ischemia/reperfusion (I/R) injury animal model was established via middle cerebral artery occlusion in this study. We set several different groups in which the rats were performed in different ways to explore the effects of TMP on blood-brainbarrier (BBB) disruption and determine whether TMP relieved BBB disruption through blocking the JAK/STAT signaling pathway. Our results showed that TMP could reduce the neurological functional loss, decrease the brain edema and BBB permeability, as well as increase the expression of tight junction proteins via inhibiting the activation of JAK/STAT signaling pathway. Overall, we demonstrated that TMP promoted neurological recovery after I/R injury via restoring the integrity and function of BBB.
- Subjects :
- Brain Infarction
0301 basic medicine
Ischemia
Apoptosis
Pharmacology
Neuroprotection
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Animals
Tetramethylpyrazine
Stat signaling
Neurons
Tight junction
business.industry
JNK Mitogen-Activated Protein Kinases
Water
JAK-STAT signaling pathway
Tyrphostins
medicine.disease
Rats
STAT Transcription Factors
030104 developmental biology
chemistry
Blood-Brain Barrier
Cytoprotection
Pyrazines
Reperfusion Injury
Blood-brain barrier disruption
business
Reperfusion injury
030217 neurology & neurosurgery
Signal Transduction
Subjects
Details
- ISSN :
- 00142999
- Volume :
- 854
- Database :
- OpenAIRE
- Journal :
- European Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....e74c57c6b0ca3d3cd0692a593294c1ea