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Atrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment
- Source :
- Endocrine
- Publication Year :
- 2020
- Publisher :
- Springer US, 2020.
-
Abstract
- Purpose To identify the volume changes of hippocampus subfields in T2DM patients with cognitive impairment and to determine how these atrophy patterns associate with impairments in different cognitive domain. Methods A total of 117 individuals were recruited, including T2DM patients with cognitive impairment (T2DM-CI) (n = 34), T2DM patients without cognitive impairment (T2DM-non-CI) (n = 36) and normal controls (NC) (n = 47). All subjects went through a 3.0 T magnetic resonance (MR) scan and a neuropsychological assessment. Hippocampal subfield volumes were processed using the FreeSurfer 6.0.0 and compared among the three groups. Partial correlation analyses were used to estimate the relationship between cognitive function and hippocampal subfield volume, with age, sex, education, and eTIV (estimated total intracranial volume) as covariants. Results The total hippocampal volume had a reduction trend among the three groups, and the significantly statistical difference only was found between T2DM-CI group and NC group. Regarding the hippocampal subfields, the volumes of left subiculum, left presubiculum, left fimbria, right CA1 and right molecular layer HP decreased significantly in the T2DM-CI group (P P P Conclusions The smaller the volume of left presubiculum, the worse the executive function, and the atrophy of the right CA1 was related to memory impairment in T2DM-CI group. However the result was the opposite in T2DM-non-CI group. There might be a compensation mechanism of hippocampus of T2DM patients before cognitive impairment.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
FreeSurfer
Hippocampus
Hippocampal formation
Correlation
03 medical and health sciences
0302 clinical medicine
Endocrinology
Atrophy
Internal medicine
Type 2 diabetes mellitus
Medicine
Memory impairment
Humans
Cognitive Dysfunction
Neuropsychological assessment
medicine.diagnostic_test
business.industry
nutritional and metabolic diseases
Magnetic resonance imaging
Cognition
medicine.disease
Hippocampal subfields
Magnetic Resonance Imaging
030104 developmental biology
Cognitive impairment
nervous system
Diabetes Mellitus, Type 2
Magnetic resonance
Cardiology
Original Article
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 15590100 and 1355008X
- Volume :
- 68
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Endocrine
- Accession number :
- edsair.doi.dedup.....e76f77874e928c615e5618cd11c42334