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Cocaine use and preterm premature rupture of membranes: improvement in neonatal outcome
- Source :
- American journal of obstetrics and gynecology. 186(6)
- Publication Year :
- 2002
-
Abstract
- Objective: Our aim was to determine whether cocaine use increases neonatal morbidity in patients with preterm premature rupture of membranes. Study Design: We reviewed records of pregnancies that were complicated with preterm premature rupture of membranes between 24 weeks to 34 weeks of gestation. Clinical characteristics and neonatal outcomes of patients who had positive results for cocaine in the urine were compared with patients with negative test results. Results: During the study period, 16.1% (85/528 patients) had a positive result in a urine screen for cocaine use. Patients who used cocaine were older and of higher gravidity and parity. When major neonatal morbidities were compared, there was improvement in morbidities that were linked to neonatal infection in patients with positive test results for cocaine, including pneumonia (3.5% vs 11.7%; P =.012) and sepsis (5.9% vs 14.7%; P =.016). Jointly, neonatal outcomes were significantly worse in the negative cocaine group (χ 2 = 5.143; P =.023). Conclusion: The association of preterm premature rupture of membranes with major neonatal morbidity was unexpectedly and significantly weaker in pregnancies complicated by cocaine use. (Am J Obstet Gynecol 2002;186:1150-4.)
- Subjects :
- Adult
Pediatrics
medicine.medical_specialty
Fetal Membranes, Premature Rupture
Urine
Infant, Newborn, Diseases
Sepsis
Cocaine
Pregnancy
Medicine
Humans
business.industry
Obstetrics
Gravidity and parity
Infant, Newborn
Pregnancy Outcome
Obstetrics and Gynecology
Bacterial Infections
Pneumonia
medicine.disease
Neonatal infection
Gestation
Female
business
Premature rupture of membranes
Subjects
Details
- ISSN :
- 00029378
- Volume :
- 186
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- American journal of obstetrics and gynecology
- Accession number :
- edsair.doi.dedup.....e7718f62308aa0e135141281807f1383