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Synergic toxic effects of food contaminant mixtures in human cells
- Source :
- Mutagenesis, Mutagenesis, Oxford University Press (OUP), 2020, 35 (5), pp.415-424. ⟨10.1093/mutage/geaa019⟩
- Publication Year :
- 2020
-
Abstract
- Humans are exposed to multiple exogenous substances, notably through food consumption. Many of these compounds are suspected to impact human health, and their combination could exacerbate their harmful effects. We previously observed in human cells that, among the six most prevalent food contaminant complex mixtures identified in the French diet, synergistic interactions between component appeared in two mixtures compared with the response with the chemicals alone. In the present study, we demonstrated in human cells that these properties are driven only by two heavy metals in each mixture: tellurium (Te) with cadmium (Cd) and Cd with inorganic arsenic (As), respectively. It appeared that the predicted effects for these binary mixtures using the mathematical model of Chou and Talalay confirmed synergism between these heavy metals. Based on different cell biology experiments (cytotoxicity, genotoxicity, mutagenesis and DNA repair inhibition experiments), a detailed mechanistic analysis of these two mixtures suggests that concomitant induction of oxidative DNA damage and decrease of their repair capacity contribute to the synergistic toxic effect of these chemical mixtures. Overall, these results may have broad implications for the fields of environmental toxicology and chemical mixture risk assessment.
- Subjects :
- DNA damage
DNA repair
[SDV]Life Sciences [q-bio]
Health, Toxicology and Mutagenesis
DNA Repair Inhibition
chemistry.chemical_element
010501 environmental sciences
Toxicology
medicine.disease_cause
01 natural sciences
03 medical and health sciences
Genetics
medicine
Cytotoxicity
Genetics (clinical)
030304 developmental biology
0105 earth and related environmental sciences
0303 health sciences
Cadmium
Mutagenesis
3. Good health
chemistry
Biochemistry
13. Climate action
[SDV.TOX]Life Sciences [q-bio]/Toxicology
Environmental toxicology
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Genotoxicity
Subjects
Details
- ISSN :
- 14643804 and 02678357
- Database :
- OpenAIRE
- Journal :
- Mutagenesis
- Accession number :
- edsair.doi.dedup.....e777d18703641ec1fa6200d44223b856