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Priapism caused by partial deficiency of tetrahydrobiopterin through hypofunction of the sympathetic neurons in sepiapterin reductase gene-disrupted mice
- Source :
- J Inherit Metab Dis. 45:621-634
- Publication Year :
- 2022
-
Abstract
- 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for aromatic L-amino acid hydroxylases, including tyrosine hydroxylase (TH), alkylglycerol monooxygenase, and three types of nitric oxide (NO) synthases (NOS). Sepiapterin reductase (SPR) catalyzes the third step of BH4 biosynthesis. SPR gene-disrupted (Spr
Details
- Language :
- English
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- J Inherit Metab Dis
- Accession number :
- edsair.doi.dedup.....e77b25d2474e296767306b36e5ddb654