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Pharmacokinetic and demographic markers of 5-fluorouracil toxicity in 181 patients on adjuvant therapy for colorectal cancer

Authors :
Silvia Toso
Roberto Padrini
Giorgio Crepaldi
Daniela Menon
Carmen Barile
L. Stievano
Mariano Ferrari
Milena Gusella
Francesco Grigoletto
A. Bononi
E. Ferrazzi
D Scapoli
Source :
Annals of Oncology. 17:1656-1660
Publication Year :
2006
Publisher :
Elsevier BV, 2006.

Abstract

BACKGROUND The relationship between 5-fluorouracil (5-FU) pharmacokinetics and toxicity following i.v. bolus administration has not been extensively studied. PATIENTS AND METHODS One hundred and eighty-one patients on adjuvant therapy with 5-FU plus leucovorin for colorectal cancer were the study population. 5-FU pharmacokinetics was determined on day 2 of the first, third, and fifth cycles; type and the grade of adverse reactions were recorded on the next cycle. RESULTS The 5-FU area under the curve (AUC) measured at the first cycle ranged between 146 and 1236 mg x min/l and was significantly correlated with drug dose, patients' body weight (BW) and gender, females having higher AUCs. These covariates explained only 23% of AUC variability. AUC and age were the only covariates which discriminated between toxic (grade > or =2) and nontoxic cycles (grade

Details

ISSN :
09237534
Volume :
17
Database :
OpenAIRE
Journal :
Annals of Oncology
Accession number :
edsair.doi.dedup.....e77ce6562b2a9c35ece748669cb6da30
Full Text :
https://doi.org/10.1093/annonc/mdl284