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Evaluation of Brugada syndrome by cardiac magnetic resonance
Evaluation of Brugada syndrome by cardiac magnetic resonance
- Source :
- The International Journal of Cardiovascular Imaging. 28:1961-1970
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Brugada syndrome (BrS) has been originally considered to occur in structural normal hearts. However recent pathological and imaging data suggest that structural and functional changes may be present in this syndrome. This study was designed to elucidate whether any macroscopic heart abnormality is detectable in patients with BrS. For this purpose we used cardiac magnetic resonance (CMR). Twenty-nine patients displaying the BrS type-1 ECG pattern and 29 healthy controls underwent CMR (1.5 Tesla). Left (LV) and right ventricular (RV) dimensions, function and regional contractility were evaluated. Late-gadolinium-enhancement (LGE) imaging was obtained in 24 patients. We found no difference between BrS patients and controls regarding LV and RV dimensions and ejection fraction. RV wall motion abnormalities (WMA) were detected in 19 patients (65.5%) and in 22 control subjects (75.9%). The majority of these WMA were attributable to areas of hypokinesia and found in the RV inferior wall. None of the patients showed LGE. No differences were detected between controls and the different subgroups of BrS patients according to symptoms, family history and spontaneous type-1 ECG pattern. BrS patients do not differ from normal subjects with regard to dimensions and global function of both LV and RV. BrS patients may show RV-WMA, however similar changes are also present in healthy subjects and may therefore represent a physiological behaviour of RV. The lack of LGE further confirms the absence of myocardial structural damage. Our results indicate that BrS seems to occur in individuals with structurally and functionally normal heart.
- Subjects :
- Adult
Gadolinium DTPA
Male
medicine.medical_specialty
Heart malformation
Heart Ventricles
Contrast Media
Ventricular Function, Left
Contractility
Electrocardiography
Young Adult
Hypokinesia
Predictive Value of Tests
Internal medicine
Humans
Medicine
Brugada syndrome
Radiology, Nuclear Medicine and imaging
cardiovascular diseases
CMR
Family history
Pathological
Cardiac imaging
Chi-Square Distribution
Ejection fraction
business.industry
Late-gadoliumn-enhancement (LGE)
fungi
Stroke Volume
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Myocardial Contraction
Case-Control Studies
Ventricular Function, Right
Cardiology
Right ventricle
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15730743 and 15695794
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- The International Journal of Cardiovascular Imaging
- Accession number :
- edsair.doi.dedup.....e7943a4ce5851a933c1ee4fefe77c1c6
- Full Text :
- https://doi.org/10.1007/s10554-012-0009-5